ReviewArthritis research & therapy2012
Inflammatory lesions in the bone marrow of rheumatoid arthritis patients: a morphological perspective.
Review in Arthritis research & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Enhancing knee MRI bone marrow lesion detection with artificial intelligence: An external validation study.Research in diagnostic and interventional imaging · 2025Article
- Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases.Life medicine · 2025Review
- [Causal relationship between autoimmune diseases and aplastic anemia: A Mendelian randomization study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- The Bone Marrow Microenvironment in Immune-Mediated Inflammatory Diseases: Implications for Mesenchymal Stromal Cell-Based Therapies.Stem cells translational medicine · 2024Review
- Preliminary MRI-based investigation of characteristics and prognosis of knee bone marrow edema in children with juvenile idiopathic arthritis.Clinical rheumatology · 2022Article
- Adiponectin Is a Component of the Inflammatory Cascade in Rheumatoid Arthritis.Journal of clinical medicine · 2022Article
- Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2Frontiers in immunology · 2021Article
- The Bone Marrow Edema Links to an Osteoclastic Environment and Precedes Synovitis During the Development of Collagen Induced Arthritis.Frontiers in immunology · 2019Article
- Clinical Applications of Synovial Biopsy.Frontiers in medicine · 2019Review
- Sequence of joint tissue inflammation during rheumatoid arthritis development.Arthritis research & therapy · 2018Article
- Different expression of chemokines in rheumatoid arthritis and osteoarthritis bone marrow.Reumatologia · 2016Article
- Adiponectin Induces Oncostatin M Expression in Osteoblasts through the PI3K/Akt Signaling Pathway.International journal of molecular sciences · 2015Article
- The draining lymph node in rheumatoid arthritis: current concepts and research perspectives.BioMed research international · 2015Review
- Aiming for a shorter rheumatoid arthritis MRI protocol: can contrast-enhanced MRI replace T2 for the detection of bone marrow oedema?European radiology · 2014Article
- Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis.Expert review of clinical immunology · 2014Review
- Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross-sectional study.Arthritis research & therapy · 2014Article
- B cells in rheumatoid arthritis: from pathogenic players to disease biomarkers.BioMed research international · 2014Review
- Treatment comparison in rheumatoid arthritis: head-to-head trials and innovative study designs.BioMed research international · 2014Review
- Characterization of DC-STAMP+ Cells in Human Bone Marrow.Journal of bone marrow research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synovial tissue stands at the epicenter of joint pathology in rheumatoid arthritis (RA). As a primary target of the disease, studies on the synovium have provided invaluable insights into the mechanisms involved in disease pathogenesis. Recent work has, however, revealed the importance of a previously unseen anatomic compartment in direct contact with the joint space, namely the subchondral bone marrow. Bone marrow edema (BME) visible on magnetic resonance imaging (MRI) is clinically meaningful in both early and late RA as it associates with future development of bone erosions and poor functional outcomes. Although the histopathologic correlates of MRI-based BME in early RA remain obscure, studies in advanced disease are consistent in describing lymphocytic inflammatory infiltrates within the subchondral marrow cavity of affected joints. In this review, we discuss the nature of bone marrow lesions in patients with RA, analyze their relationship with synovitis, and explore their potential contribution to the pathological processes of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.