ArticleGenome biology2012
Phylogeographic variation in recombination rates within a global clone of methicillin-resistant Staphylococcus aureus.
Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75 citing papers in PubMed, 126 citations in OpenAlex.
- Recombination shapes the dynamics of selective constraint in global populations of human gut bacteria.PLoS biology · 2026Article
- Fluoroquinolone resistance without fluoroquinolone use; the genie is truly out of the bottle.Frontiers in microbiology · 2026Review
- Dynamics of dN/dS within recombining bacterial populations.bioRxiv : the preprint server for biology · 2025Article
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- A cross-sectional molecular epidemiological study of biofilm-producing methicillin-resistant Staphylococcus aureus.Medicine · 2025Observational
- Methicillin-sensitiveMicrobial genomics · 2025Article
- Sequencing a CC239-MRSA-III with a novel composite SCC mec element from Kuwait.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
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- Recombination-mediated dissemination of Methicillin-resistant S. aureus clonal complex 1 in the Egyptian health care settings.Annals of clinical microbiology and antimicrobials · 2023Article
- Molecular Surveillance of MRSA in Raw Milk Provides Insight into MRSA Cross Species Evolution.Microbiology spectrum · 2023Article
- A scalable analytical approach from bacterial genomes to epidemiology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin.Cell chemical biology · 2022Article
- Core genes can have higher recombination rates than accessory genes within global microbial populations.eLife · 2022Article
- Systems-Based Approach for Optimization of Assembly-Free Bacterial MLST Mapping.Life (Basel, Switzerland) · 2022Article
- Clonal Diversity and Epidemiological Characteristics of ST239-MRSA Strains.Frontiers in cellular and infection microbiology · 2022Article
- Article
- Significant variability exists in the cytotoxicity of global methicillin-resistantMicrobiology (Reading, England) · 2021Article
- Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus.Genome biology and evolution · 2021Article
- The effect of recombination on the evolution of a population ofGenome research · 2021Article
- Genomic epidemiology of methicillin-resistant and -susceptible Staphylococcus aureus from bloodstream infections.BMC infectious diseases · 2021Article
15 more citing papers are in PubMed but not listed here.
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12 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundNext-generation sequencing (NGS) is a powerful tool for understanding both patterns of descent over time and space (phylogeography) and the molecular processes underpinning genome divergence in pathogenic bacteria. Here, we describe a synthesis between these perspectives by employing a recently developed Bayesian approach, BRATNextGen, for detecting recombination on an expanded NGS dataset of the globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clone ST239.
resultsThe data confirm strong geographical clustering at continental, national and city scales and demonstrate that the rate of recombination varies significantly between phylogeographic sub-groups representing independent introductions from Europe. These differences are most striking when mobile non-core genes are included, but remain apparent even when only considering the stable core genome. The monophyletic ST239 sub-group corresponding to isolates from South America shows heightened recombination, the sub-group predominantly from Asia shows an intermediate level, and a very low level of recombination is noted in a third sub-group representing a large collection from Turkey.
conclusionsWe show that the rapid global dissemination of a single pathogenic bacterial clone results in local variation in measured recombination rates. Possible explanatory variables include the size and time since emergence of each defined sub-population (as determined by the sampling frame), variation in transmission dynamics due to host movement, and changes in the bacterial genome affecting the propensity for recombination.
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