Evidence map›Paper›PMID 23270605›Full record

ReviewNeuropharmacology2014

Dynamic regulation of neurotransmitter specification: relevance to nervous system homeostasis.

Laura N Borodinsky, Yesser Hadj Belgacem, Immani Swapna, Eduardo Bouth Sequerra

Abstract readReview
In one paragraph

Review in Neuropharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Mixed neurotransmission in the hippocampal mossy fibers.Frontiers in cellular neuroscience · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laura N BorodinskyDepartment of Physiology & Membrane Biology, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, 2425 Stockton Blvd, Sacramento, CA 95817, USA. Electronic address: lnborodinsky@ucdavis.edu.
Yesser Hadj BelgacemDepartment of Physiology & Membrane Biology, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, 2425 Stockton Blvd, Sacramento, CA 95817, USA.
Immani SwapnaDepartment of Physiology & Membrane Biology, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, 2425 Stockton Blvd, Sacramento, CA 95817, USA.
Eduardo Bouth SequerraDepartment of Physiology & Membrane Biology, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, 2425 Stockton Blvd, Sacramento, CA 95817, USA.

Funding

Spinal Cord Development: Interplay Between Electrical Activity and Sonic HedgehogR01NS073055 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BORODINSKY, LAURA NOEMI · 2011 to 2015
$1.6M
NINDS NIH HHS R01 NS073055NINDS NIH HHS R01NS073055
6 · The paper itself

Abstract

During nervous system development the neurotransmitter identity changes and coexpression of several neurotransmitters is a rather generalized feature of developing neurons. In the mature nervous system, different physiological and pathological circumstances recreate this phenomenon. The rules of neurotransmitter respecification are multiple. Among them, the goal of assuring balanced excitability appears as an important driving force for the modifications in neurotransmitter phenotype expression. The functional consequences of these dynamic revisions in neurotransmitter identity span a varied range, from fine-tuning the developing neural circuit to modifications in addictive and locomotor behaviors. Current challenges include determining the mechanisms underlying neurotransmitter phenotype respecification and how they intersect with genetic programs of neuronal specialization. This article is part of the Special Issue entitled 'Homeostatic Synaptic Plasticity'.

Indexed as

HomeostasisAnimalsHumansNeurotransmitter AgentsSynapsesNeurotransmitter AgentsActivity-dependentNeurotransmitter phenotype

Identifiers

PMID23270605
PMCPMC3628948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.