Trial reportChildhood obesity (Print)2013
Oxidative stress and cardiovascular risk in overweight children in an exercise intervention program.
Trial report in Childhood obesity (Print), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Effects of exercise on cardiorespiratory fitness in children and adolescents with overweight and obesity: a systematic review and meta-analysis of 72 randomized controlled trials.BMC public health · 2025Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years.The Cochrane database of systematic reviews · 2017Pooled it
- The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Eight weeks of moderate aerobic exercise on body composition and markers of inflammation and oxidative stress in middle-aged obese females.Journal of exercise rehabilitation · 2025Article
- Diet Biofunctionality in Modulating Cardiovascular Parameters in Obese Patients After Bioenteric Intragastric Balloon Bariatric Surgery.Nutrients · 2024Article
- The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases.International journal of molecular sciences · 2023Review
- Metabolic syndrome, adiposity, diet, and emotional eating are associated with oxidative stress in adolescents.Frontiers in nutrition · 2023Article
- Systemic Inflammation, Oxidative Stress and Cardiovascular Health in Children and Adolescents: A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Aerobic exercise is an independent determinant of levels of inflammation and oxidative stress in middle-aged obese females.Journal of exercise rehabilitation · 2022Article
- Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status.Frontiers in nutrition · 2022Review
- Effects of Telephone Follow-Up Intervention on %Body Fat, Inflammatory Cytokines, and Oxidative Stress in Obese Hispanic Children.International journal of environmental research and public health · 2019Article
- Article
- Prenatal phthalate exposure and 8-isoprostane among Mexican-American children with high prevalence of obesity.Journal of developmental origins of health and disease · 2017Article
- The isoprostanes--25 years later.Biochimica et biophysica acta · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study aimed to determine whether oxidative stress was related to cardiovascular risk indices in children, and whether an exercise intervention would reduce oxidative stress.
methodsA randomized trial of two different doses of exercise and a no-exercise control group included 112 overweight and obese children, 7-11 years old. Plasma isoprostane levels were obtained at baseline and after the intervention. Cross-sectional analysis of oxidative stress and metabolic markers at baseline was performed. The effect of the exercise training on oxidative stress was tested.
resultsLower isoprostane levels were observed in blacks. At baseline, isoprostane was positively related to measures of fatness (BMI, waist circumference, percent body fat), insulin resistance and β-cell function (fasting insulin, insulin area under the curve, Matsuda index, disposition index, oral disposition index), and several lipid markers (low-density lipoprotein, triglycerides, total cholesterol), and inversely with fitness [peak oxygen consumption (VO(2))], independent of race, sex, and cohort. No relation was found with visceral fat, blood pressure, or glycemia. Independent of percent body fat, isoprostane predicted triglycerides, β=0.23, total cholesterol-to-high-density lipoprotein (TC/HDL) ratio, β=0.23, and insulin resistance (insulin area under the curve, β=0.24, Matsuda index, β=-0.21, oral disposition index, β=0.33). Exercise did not reduce oxidative stress levels, despite reduced fatness and improved fitness in these children.
conclusionsIsoprostane levels were related to several markers of cardiovascular risk at baseline; however, despite reduced fatness and improved fitness, no effect of exercise was observed on isoprostane levels. To our knowledge, this is the first report in children to demonstrate a correlation of oxidative stress with disposition index, fitness, and TC/HDL ratio, the first to test the effect on oxidative stress of an exercise intervention that reduced body fat, and the first such exercise intervention study to include a substantial proportion of black children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.