ArticleJournal of the Royal Society, Interface2013
The importance of amino acid interactions in the crystallization of hydroxyapatite.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 102 citations in OpenAlex.
- Additive-specific modulation of non-classical nucleation pathways.Nature communications · 2026Article
- Memfractance of Proteinoids.ACS omega · 2024Article
- Mg, Zn Substituted Calcium Phosphates-Thermodynamic Modeling, Biomimetic Synthesis in the Presence of Low-Weight Amino Acids and High Temperature Properties.Materials (Basel, Switzerland) · 2023Article
- The remineralization effect of GERM CLEAN on early human enamel caries lesions in vitro.Scientific reports · 2023Article
- Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering.Biopolymers · 2023Review
- Nuclear Magnetic Resonance and Metadynamics Simulations Reveal the Atomistic Binding of l-Serine andChemistry of materials : a publication of the American Chemical Society · 2022Article
- Hydroxyapatite/L-Lysine Composite Coating as Glassy Carbon Electrode Modifier for the Analysis and Detection of Nile Blue A.Materials (Basel, Switzerland) · 2022Article
- Hydroxyapatite-decorated Fmoc-hydrogel as a bone-mimicking substrate for osteoclast differentiation and culture.Acta biomaterialia · 2022Article
- Precipitation at Room Temperature as a Fast and Versatile Method for Calcium Phosphate/TiONanomaterials (Basel, Switzerland) · 2021Article
- The Influence of Different Classes of Amino Acids on Calcium Phosphates Seeded Growth.Materials (Basel, Switzerland) · 2020Article
- Effects of amino acids on conversion of calcium carbonate to hydroxyapatite.RSC advances · 2020Article
- Identification of a calcium phosphoserine coordination network in an adhesive organo-apatitic bone cement system.Acta biomaterialia · 2020Article
- Phosphoserine Functionalized Cements Preserve Metastable Phases, and Reprecipitate Octacalcium Phosphate, Hydroxyapatite, Dicalcium Phosphate, and Amorphous Calcium Phosphate, during Degradation, In Vitro.Journal of functional biomaterials · 2019Article
- Impact of Side Chain Polarity on Non-Stoichiometric Nano-Hydroxyapatite Surface Functionalization with Amino Acids.Scientific reports · 2018Article
- Amino acid adsorption on anatase (101) surface at vacuum and aqueous solution: a density functional study.Journal of molecular modeling · 2018Article
- Worsening calcification propensity precedes all-cause and cardiovascular mortality in haemodialyzed patients.Scientific reports · 2017Article
- On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity.Scientific reports · 2017Article
- Quantifying the efficiency of Hydroxyapatite Mineralising Peptides.Scientific reports · 2017Article
- The role of amino acids in hydroxyapatite mineralization.Journal of the Royal Society, Interface · 2016Review
- Identification of Specific Hydroxyapatite {001} Binding Heptapeptide by Phage Display and Its Nucleation Effect.Materials (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-collagenous proteins (NCPs) inhibit hydroxyapatite (HA; Ca(5)(PO(4))(3)OH) formation in living organisms by binding to nascent nuclei of HA and preventing their further growth. Polar and charged amino acids (AAs) are highly expressed in NCPs, and the negatively charged ones, such as glutamic acid (Glu) and phosphoserine (P-Ser) seem to be mainly responsible for the inhibitory effect of NCPs. Despite the recognized importance of these AAs on the behaviour of NCPs, their specific effect on HA crystallization is still unclear, and controversial results have been reported concerning the efficacy of HA inhibition of positively versus negatively charged AAs. We focused on a positively charged (arginine, Arg) and a negatively charged (Glu) AA, and their combination in the same solution. We studied their inhibitory effect on HA nucleation and growth at physiological temperature and pH and we determined the mechanism by which they can affect HA crystallization. Our results showed a strong inhibitory effect of Arg on HA nucleation; however, Glu was more effective in inhibiting HA crystal growth during the growth stage. The combination of Glu and Arg was less effective in controlling HA nucleation, but it inhibited HA crystal growth. We attributed these differences to the stability of complexes formed between AAs and calcium and phosphate ions at the nucleation stage, and in bonding strength of AAs to HA crystal faces during the growth stage. The AAs also influenced the morphology of synthesized HA. Presence of either Arg or Glu resulted in the formation of spherulites consisting of preferentially oriented nanoplatelets orientation. This was attributed to kinetic factors favoring growth front nucleation (GFN) mechanism.
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