ArticleAmerican journal of physiology. Renal physiology2013
Immunosuppression preserves renal autoregulatory function and microvascular P2X(1) receptor reactivity in ANG II-hypertensive rats.
Article in American journal of physiology. Renal physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Prevention of hypertension-induced renal vascular dysfunction through a p66Shc-targeted mechanism.American journal of physiology. Renal physiology · 2025Article
- Targeting P2X Receptors-Current Progress in Sepsis.International journal of inflammation · 2025Review
- [New concepts in the physiopathology of hypertension. Purinergic receptors].Archivos de cardiologia de Mexico · 2024Review
- Autoregulatory mission impossible: when afferent arterioles lose contractility.Kidney international · 2023Article
- Purinoceptor: a novel target for hypertension.Purinergic signalling · 2023Review
- Restoration of afferent arteriolar autoregulatory behavior in ischemia-reperfusion injury in rat kidneys.American journal of physiology. Renal physiology · 2021Article
- Purinoceptors, renal microvascular function and hypertension.Physiological research · 2020Review
- Antagonism of major histocompatibility complex class II invariant chain peptide during chronic lipopolysaccharide treatment rescues autoregulatory behavior.American journal of physiology. Renal physiology · 2019Article
- Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: An update.Pharmacological research · 2019Review
- Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles.Acta physiologica (Oxford, England) · 2018Article
- Macrophage Depletion Lowered Blood Pressure and Attenuated Hypertensive Renal Injury and Fibrosis.Frontiers in physiology · 2018Article
- Acute toll-like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour.Acta physiologica (Oxford, England) · 2017Article
- Impaired Aortic Contractility to Uridine Adenosine Tetraphosphate in Angiotensin II-Induced Hypertensive Mice: Receptor Desensitization?American journal of hypertension · 2017Article
- Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats.American journal of physiology. Renal physiology · 2016Article
- Endothelin contributes to blunted renal autoregulation observed with a high-salt diet.American journal of physiology. Renal physiology · 2015Article
- Endothelin and the renal microcirculation.Seminars in nephrology · 2015Review
- Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension.American journal of physiology. Renal physiology · 2015Article
- Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature.Journal of the American Society of Nephrology : JASN · 2014Article
- High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism.American journal of physiology. Renal physiology · 2014Article
- Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Autoregulation is critical for protecting the kidney against arterial pressure elevation and is compromised in some forms of hypertension. Evidence indicates that activated lymphocytes contribute importantly to cardiovascular injury in hypertension. We hypothesized that activated lymphocytes contribute to renal vascular dysfunction by impairing autoregulation and P2X(1) receptor signaling in ANG II-infused hypertensive rats. Male Sprague-Dawley rats receiving ANG II infusion were treated with a lymphocyte proliferation inhibitor, mycophenolate mofetil (MMF) for 2 wk. Autoregulation was assessed in vitro and in vivo using the blood-perfused juxtamedullary nephron preparation and anesthetized rats, respectively. ANG II-treated rats exhibited impaired autoregulation. At the single vessel level, pressure-mediated afferent arteriolar vasoconstriction was significantly blunted (P < 0.05 vs. control rats). At the whole kidney level, renal blood flow passively decreased as renal perfusion pressure was reduced. MMF treatment did not alter the ANG II-induced hypertensive state; however, MMF did preserve autoregulation. The autoregulatory profiles in both in vitro or in vivo settings were similar to the responses from control rats despite persistent hypertension. Autoregulatory responses are linked to P2X(1) receptor activation. Accordingly, afferent arteriolar responses to ATP and the P2X(1) receptor agonist β,γ-methylene ATP were assessed. ATP- or β,γ-methylene ATP-induced vasoconstriction was significantly attenuated in ANG II-infused hypertensive rats but was normalized by MMF treatment. Moreover, MMF prevented elevation of plasma transforming growth factor-β1 concentration and lymphocyte and macrophage infiltration in ANG II-infused kidneys. These results suggest that anti-inflammatory treatment with MMF prevents lymphocyte infiltration and preserves autoregulation in ANG II-infused hypertensive rats, likely by normalizing P2X(1) receptor activation.
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