SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prognostic significance of matrix metalloproteinase 9 expression in osteosarcoma: A meta-analysis of 16 studies.Medicine · 2018Pooled it
- A systematic review of matrix metalloproteinase 9 as a biomarker of survival in patients with osteosarcoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Prognostic significance of matrix metalloproteinase-7 in gastric cancer survival: a meta-analysis.PloS one · 2014Pooled it
- Prognostic Role of Matrix Metalloproteinases in Cervical Cancer: A Meta-Analysis.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment.Frontiers in oncology · 2021Article
- Review
- Targeting and imaging colorectal cancer by activatable cell-penetrating peptides.American journal of translational research · 2020Article
- The downregulation of Rap1 GTPase-activating protein is associated with a poor prognosis in colorectal cancer and may impact on tumor progression.Oncology letters · 2018Article
- Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions.Oncotarget · 2018Article
- Article
- High expression of MMP9 in glioma affects cell proliferation and is associated with patient survival rates.Oncology letters · 2017Article
- Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum.World journal of gastroenterology · 2016Review
- Do matrix metalloproteinases represent reliable circulating biomarkers in colorectal cancer?British journal of cancer · 2016Article
- Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification.Biomicrofluidics · 2016Article
- Endoscopy-guided orthotopic implantation of colorectal cancer cells results in metastatic colorectal cancer in mice.Clinical & experimental metastasis · 2016Article
- Endocannabinoid system as a regulator of tumor cell malignancy - biological pathways and clinical significance.OncoTargets and therapy · 2016Review
- The Effects of NDRG2 Overexpression on Cell Proliferation and Invasiveness of SW48 Colorectal Cancer Cell Line.Iranian journal of medical sciences · 2015Article
- Serum matrix metalloproteinase-9 in colorectal cancer family-risk population screening.Scientific reports · 2015Article
- The matrix metalloproteinase-7 and pro-enzyme of metalloproteinase-1 as a potential marker for patients with rectal cancer without distant metastasis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Colorectal cancer and basement membranes: clinicopathological correlations.Gastroenterology research and practice · 2014Review
Corrections and comments
- Retraction · 2017-04-20Compromised Peer Review · Investigation by Journal/Publisher · · Journal published by SAGE starting in 2017
- Retracted
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinase-9 (MMP-9) is an important member of the matrix metalloproteinase family and is considered to be involved in the invasion and metastasis of cancer cells. Many studies were published to assess the prognostic role of MMP-9 overexpression in patients with colorectal cancer, but the findings from those studies were inconsistent. We searched eligible studies in Pubmed, Embase, and Web of Science databases. Thirteen studies with a total of 2, 390 CRC patients were finally included into the meta-analysis. The pooled hazard ratios (HRs) with the corresponding 95 % confidence interval (95 % CIs) for overall and progression-free survival were calculated by using meta-analysis. There were nine studies with a total of 1,674 colorectal cancer patients relating the progression-free survival, and eight studies with a total of 1,379 colorectal cancer patients relating the overall survival. Overall, MMP-9 overexpression was associated with poorer progression-free survival in patients with colorectal cancer (fixed-effects HR 1.81, 95 % CI 1.48-2.20, P < 0.001; random-effects HR 1.92, 95 % CI 1.46-2.53, P < 0.001). In addition, MMP-9 overexpression was also associated with poorer overall survival in patients with colorectal cancer (fixed-effects HR 1.74, 95 % CI 1.39-2.19, P < 0.001; random-effects HR 1.78, 95 % CI 1.31-2.41, P < 0.001). MMP-9 expression is associated with the prognosis of patients with colorectal cancer, and patients with higher MMP-9 expression have poorer survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.