SynthesisNeurology2013
Drug therapy for solitary cysticercus granuloma: a systematic review and meta-analysis.
Synthesis in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The effectiveness of anti-inflammatory and anti-seizure medication for individuals with single enhancing lesion neurocysticercosis: A meta-analysis and expert group-based consensus recommendations.PLoS neglected tropical diseases · 2021Pooled it
- Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).The American journal of tropical medicine and hygiene · 2018Guideline
- A longitudinal analysis of albendazole treatment effect on neurocysticercosis cyst evolution using multistate models.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019Trial
- Exploring the complex associations over time among albendazole treatment, cyst evolution, and seizure outcomes in neurocysticercosis.Epilepsia · 2019Trial
- The effect of albendazole treatment on non-seizure outcomes in patients with symptomatic neurocysticercosis.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2018Trial
- Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after.Epilepsia · 2014Trial
- Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: a double-blind, randomised controlled trial.The Lancet. Infectious diseases · 2014Trial
- A Case Report of Extracranial Intramuscular Cysticercosis As Soft Tissue Swelling in the Forearm and Thenar Eminence.Cureus · 2025Article
- Article
- Frequency and Determinant Factors for Calcification in Neurocysticercosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Neurocysticercosis. A frequent cause of seizures, epilepsy, and other neurological morbidity in most of the world.Journal of the neurological sciences · 2021Review
- A Clinical Prognostic Scoring System for Neurocysticercosis.Journal of neurosciences in rural practice · 2021Article
- Taenia solium Cysticercosis and Its Impact in Neurological Disease.Clinical microbiology reviews · 2020Review
- Zoonotic and vector-borne parasites and epilepsy in low-income and middle-income countries.Nature reviews. Neurology · 2020Review
- A Personal Account Regarding the Origin and Evolution of Controversies in the Management of Neurocysticercosis.The American journal of tropical medicine and hygiene · 2019Article
- Pediatric Neurocysticercosis.Indian journal of pediatrics · 2019Review
- Solitary Brain Mass in a Patient with Seizures: An Unexpected Infectious Etiology.Diseases (Basel, Switzerland) · 2018Article
- Disease Centered Around Calcified Taenia solium Granuloma.Trends in parasitology · 2017Review
- Prevalence, Response to Cysticidal Therapy, and Risk Factors for Persistent Seizure in Indian Children with Neurocysticercosis.International journal of pediatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveThe effectiveness of anthelminthic and corticosteroid drug therapy in parenchymal neurocysticercosis is well established. The treatment of parenchymal solitary cysticercus granuloma (SCG), however, remains controversial. We attempted to obtain a consistent estimate of the efficacy of anthelminthic and corticosteroid drug treatment in SCG.
methodsRandomized-controlled trials (RCTs) comparing rates of seizure freedom, granuloma resolution, and residual calcification in individuals with SCG treated with anthelminthic or corticosteroid drugs with those treated with antiepileptic drugs (AEDs) alone were systematically reviewed and quantified using fixed- or random-effects meta-analysis.
resultsFifteen RCTs were identified for inclusion. Ten RCTs assigned 765 people with SCG to AED treatment with or without anthelminthic drug (albendazole) treatment. A further 5 RCTs assigned 457 people with SCG to AED treatment with or without corticosteroid drugs. Anthelminthic treatment was associated with significantly increased rates of seizure freedom (nonevent odds ratio: 2.45; 95% confidence interval: 1.49-4.03; p = 0.0004) and significantly higher rates of granuloma resolution (odds ratio: 2.09; 95% confidence interval: 1.41-3.00; p = 0.0003), but did not alter the risk of residual calcification. Corticosteroid treatment was not significantly associated with any outcome.
conclusionsAnthelminthic treatment with albendazole provides improved rates of seizure freedom and hastens resolution of the granuloma. The role of corticosteroid treatment remains uncertain. The benefits (or lack thereof in the case of corticosteroids) are consistent when measured across different time points after treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.