ArticleObesity surgery2013
Longitudinal assessment of food intake, fecal energy loss, and energy expenditure after Roux-en-Y gastric bypass surgery in high-fat-fed obese rats.
Article in Obesity surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Roux-en-Y gastric bypass promotes white adipose tissue browning and systemic metabolic recovery in obese type 2 diabetic mice.BMC endocrine disorders · 2026Article
- Weight loss in adult male Wistar rats by Roux-en-Y gastric bypass is primarily explained by caloric intake reduction and presurgery body weight.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Effects of gastric bypass on the digestibility and postprandial metabolic fate of 15N dietary protein in rats.PloS one · 2024Article
- Regulation of body weight: Lessons learned from bariatric surgery.Molecular metabolism · 2023Review
- Vertical sleeve gastrectomy induces enteroendocrine cell differentiation of intestinal stem cells through bile acid signaling.JCI insight · 2022Article
- The Effects of Roux-en-Y Gastric Bypass on Glucose- vs. Fructose-Associated Conditioned Flavor Preference.Physiology & behavior · 2022Article
- Recommendations for evaluation of bladder and bowel function in pre-clinical spinal cord injury research.The journal of spinal cord medicine · 2020Review
- Increased Energy Expenditure and Energy Loss Through Feces Contribute to the Long-Term Outcome of Roux-en-Y Gastric Bypass in a Diet-Induced Obese Mouse Model.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Hepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats.Chinese journal of integrative medicine · 2019Article
- Regulation of intestinal growth in response to variations in energy supply and demand.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2018Review
- Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species.Cell metabolism · 2018Article
- Effects of Bariatric Surgery on Change of Brown Adipocyte Tissue and Energy Metabolism in Obese Mice.Obesity surgery · 2018Article
- The Role of GLP-1 in the Metabolic Success of Bariatric Surgery.Endocrinology · 2017Review
- Do Food Preferences Change After Bariatric Surgery?Current atherosclerosis reports · 2017Review
- Bile acids and bariatric surgery.Molecular aspects of medicine · 2017Review
- The Use of Rat and Mouse Models in Bariatric Surgery Experiments.Frontiers in nutrition · 2016Review
- Recent advances in metabolic and bariatric surgery.F1000Research · 2016Review
- Effects of high-fat diet and gastric bypass on neurons in the caudal solitary nucleus.Physiology & behavior · 2015Article
- Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning.Molecular metabolism · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe efficacy of Roux-en-Y gastric bypass (RYGB) surgery to produce weight loss has been well-documented, but few studies have measured the key components of energy balance, food intake, and energy expenditure longitudinally.
methodsMale Sprague-Dawley rats on a high-fat diet underwent either RYGB, sham operation, or pair feeding and were compared to chow-fed lean controls. Body weight and composition, food intake and preference, energy expenditure, fecal output, and gastric emptying were monitored before and up to 4 months after intervention.
resultsDespite the recovery of initially decreased food intake to levels slightly higher than before surgery and comparable to sham-operated rats after about 1 month, RYGB rats maintained a lower level of body weight and fat mass for 4 months that was not different from chow-fed age-matched controls. Energy expenditure corrected for lean body mass at 1 and 4 months after RYGB was not different from presurgical levels and from all other groups. Fecal energy loss was significantly increased at 6 and 16 weeks after RYGB compared to sham operation, and there was a progressive decrease in fat preference after RYGB.
conclusionsIn this rat model of RYGB, sustained weight loss is achieved by a combination of initial hypophagia and sustained increases in fecal energy loss, without change in energy expenditure per lean mass. A shift away from high-fat towards low-fat/high-carbohydrate food preference occurring in parallel suggests long-term adaptive mechanisms related to fat absorption.
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