Evidence map›Paper›PMID 23269436›Full record

ReviewCellular and molecular life sciences : CMLS2013

Regulatory circuits controlling vascular cell calcification.

Tamer Sallam, Henry Cheng, Linda L Demer, Yin Tintut

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. TheCurrent issues in molecular biology · 2024
    Article
  3. IL-1β in atherosclerotic vascular calcification: From bench to bedside.International journal of biological sciences · 2021
    Review
  4. Molecular Aspects of Thyroid Calcification.International journal of molecular sciences · 2020
    Review
  5. Article
  6. Atherosclerotic Calcification: Wnt Is the Hint.Journal of the American Heart Association · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015
    Article
  11. Review
  12. Review
  13. Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro.Matrix biology : journal of the International Society for Matrix Biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tamer SallamDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Center for the Health Sciences, A2-237, 10833 Le Conte Ave., Los Angeles, CA, 90095-1679, USA.
Henry Cheng
Linda L Demer
Yin Tintut
University of California, Los Angeles · USOklahoma State University Center for Health Sciences · US

Funding

RANKL/OPG-Mediated Control of Vascular CalcificationR01HL081202 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L. · 2006 to 2010
$1.9M
Regulation of PTH-induced Osteoanabolism by Inflammatory LipidsR01DK081346 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TINTUT, YIN · 2009 to 2013
$1.8M
Role of Inhibitory SMADs in Calcific Aortic Valve DiseaseR01HL114709 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2012 to 2015
$1.5M
Role of Lymphatic Clearance in Lipid-Induced Calcific Vasculopathy and Bone LossR21HL109628 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2011 to 2012
$424k
NHLBI NIH HHS HL081202NHLBI NIH HHS HL109628NHLBI NIH HHS R01 HL081202NHLBI NIH HHS R01 HL114709NHLBI NIH HHS R21 HL109628NIDDK NIH HHS DK081346NIDDK NIH HHS R01 DK081346
6 · The paper itself

Abstract

Vascular calcification is a common feature of chronic kidney disease, cardiovascular disease, and aging. Such abnormal calcium deposition occurs in medial and/or intimal layers of blood vessels as well as in cardiac valves. Once considered a passive and inconsequential finding, the presence of calcium deposits in the vasculature is widely accepted as a predictor of increased morbidity and mortality. Recognition of the importance of vascular calcification in health is driving research into mechanisms that govern its development, progression, and regression. Diverse, but highly interconnected factors, have been implicated, including disturbances in lipid metabolism, oxidative stress, inflammatory cytokines, and mineral and hormonal balances, which can lead to formation of osteoblast-like cells in the artery wall. A tight balance of procalcific and anticalcific regulators dictates the extent of disease. In this review, we focus on the main regulatory circuits modulating vascular cell calcification.

Indexed as

CalcinosisCardiovascular DiseasesHumansRenal Insufficiency, ChronicVascular CalcificationVascular Diseases

Identifiers

PMID23269436
PMCPMC3638052
OpenAlexW2046527839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.