ArticleCellular and molecular life sciences : CMLS2013
Bimodal processing of olfactory information in an amphibian nose: odor responses segregate into a medial and a lateral stream.
Article in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 56 citations in OpenAlex.
- Calcium imaging of adult olfactory epithelium reveals amines as important odor class in fish.Cell and tissue research · 2024Article
- Functional odor map heterogeneity is based on multifaceted glomerular connectivity in larvaliScience · 2023Article
- Electrophysiological responses to conspecific odorants in Xenopus laevis show potential for chemical signaling.PloS one · 2022Article
- Distinct interhemispheric connectivity at the level of the olfactory bulb emerges during Xenopus laevis metamorphosis.Cell and tissue research · 2021Article
- Resolving different presynaptic activity patterns within single olfactory glomeruli of Xenopus laevis larvae.Scientific reports · 2021Article
- Olfactory subsystems in the peripheral olfactory organ of anuran amphibians.Cell and tissue research · 2021Review
- Olfaction across the water-air interface in anuran amphibians.Cell and tissue research · 2021Review
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Conservation of Glomerular Organization in the Main Olfactory Bulb of Anuran Larvae.Frontiers in neuroanatomy · 2020Article
- Assessing predator-prey interactions in a chemically altered aquatic environment: the effects of DDT on Xenopus laevis and Culex sp. larvae interactions and behaviour.Ecotoxicology (London, England) · 2019Article
- Bcl11b controls odorant receptor class choice in mice.Communications biology · 2019Article
- Excreted Steroids in Vertebrate Social Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis.Cellular and molecular life sciences : CMLS · 2017Article
- A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine.Scientific reports · 2017Article
- Functional Reintegration of Sensory Neurons and Transitional Dendritic Reduction of Mitral/Tufted Cells during Injury-Induced Recovery of the LarvalFrontiers in cellular neuroscience · 2017Article
- One Special Glomerulus in the Olfactory Bulb of Xenopus laevis Tadpoles Integrates a Broad Range of Amino Acids and Mechanical Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Evolving Neural and Genetic Architecture of Vertebrate Olfaction.Current biology : CB · 2016Review
- Different expression domains for two closely related amphibian TAARs generate a bimodal distribution similar to neuronal responses to amine odors.Scientific reports · 2015Article
- Integrating temperature with odor processing in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Sensory afferent segregation in three-eared frogs resemble the dominance columns observed in three-eyed frogs.Scientific reports · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to the single sensory surface present in teleost fishes, several spatially segregated subsystems with distinct molecular and functional characteristics define the mammalian olfactory system. However, the evolutionary steps of that transition remain unknown. Here we analyzed the olfactory system of an early diverging tetrapod, the amphibian Xenopus laevis, and report for the first time the existence of two odor-processing streams, sharply segregated in the main olfactory bulb and partially segregated in the olfactory epithelium of pre-metamorphic larvae. A lateral odor-processing stream is formed by microvillous receptor neurons and is characterized by amino acid responses and Gαo/Gαi as probable signal transducers, whereas a medial stream formed by ciliated receptor neurons is characterized by responses to alcohols, aldehydes, and ketones, and Gαolf/cAMP as probable signal transducers. To reveal candidates for the olfactory receptors underlying these two streams, the spatial distribution of 12 genes from four olfactory receptor gene families was determined. Several class II and some class I odorant receptors (ORs) mimic the spatial distribution observed for the medial stream, whereas a trace amine-associated receptor closely parallels the spatial pattern of the lateral odor-processing stream. Other olfactory receptors (some class I odorant receptors and vomeronasal type 1 receptors) and odor responses (to bile acids, amines) were not lateralized, the latter not even in the olfactory bulb, suggesting an incomplete segregation. Thus, the olfactory system of X. laevis exhibits an intermediate stage of segregation and as such appears well suited to investigate the molecular driving forces behind olfactory regionalization.
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