ArticleAmerican journal of physiology. Endocrinology and metabolism2013
Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Changes in Ghrelin and Glucagon following a Low Glycemic Load Diet in Women with PCOS.The Journal of clinical endocrinology and metabolism · 2021Trial
- The provisioned primate: patterns of obesity across lemurs, monkeys, apes and humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Osteology of the Hamadryas Baboon (Animals : an open access journal from MDPI · 2023Article
- Islet Health, Hormone Secretion, and Insulin Responsivity with Low-Carbohydrate Feeding in Diabetes.Metabolites · 2020Review
- Pauci-immune glomerulonephritis in a captive chimpanzee (Pan troglodytes), and a review of spontaneous cases in animals.Journal of medical primatology · 2016Review
- Central GIP signaling stimulates peripheral GIP release and promotes insulin and pancreatic polypeptide secretion in nonhuman primates.American journal of physiology. Endocrinology and metabolism · 2016Article
- Impact of high-fat, low-carbohydrate diet on myocardial substrate oxidation, insulin sensitivity, and cardiac function after ischemia-reperfusion.American journal of physiology. Heart and circulatory physiology · 2016Article
- Pancreatic neuroendocrine tumors in twelve baboons (Papio spp.).Journal of medical primatology · 2016Article
- Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer.Oncogenesis · 2016Review
- Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance.Diabetes · 2015Article
- Understanding the control of ingestive behavior in primates.Hormones and behavior · 2014Review
- Nonhuman primate lung decellularization and recellularization using a specialized large-organ bioreactor.Journal of visualized experiments : JoVE · 2013Article
- Effects of a Western-type diet on plasma lipids and other cardiometabolic risk factors in African green monkeys (Chlorocebus aethiops sabaeus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
We established a model of chronic portal vein catheterization in an awake nonhuman primate to provide a comprehensive evaluation of the metabolic response to low-carbohydrate/high-fat (LCHF; 20% carbohydrate and 65% fat) and high-carbohydrate/low-fat (HCLF; 65% carbohydrate and 20% fat) meal ingestion. Each meal was given 1 wk apart to five young adult (7.8 ± 1.3 yr old) male baboons. A [U-¹³C]glucose tracer was added to the meal, and a [6,6-²H₂]glucose tracer was infused systemically to assess glucose kinetics. Plasma areas under the curve (AUCs) of glucose, insulin, and C-peptide in the femoral artery and of glucose and insulin in the portal vein were higher (P ≤ 0.05) after ingestion of the HCLF compared with the LCHF meal. Compared with the LCHF meal, the rate of appearance of ingested glucose into the portal vein and the systemic circulation was greater after the HCLF meal (P < 0.05). Endogenous glucose production decreased by ∼40% after ingestion of the HCLF meal but was not affected by the LCHF meal (P < 0.05). Portal vein blood flow increased (P < 0.001) to a similar extent after consumption of either meal. In conclusion, a LCHF diet causes minimal changes in the rate of glucose appearance in both portal and systemic circulations, does not affect the rate of endogenous glucose production, and causes minimal stimulation of C-peptide and insulin. These observations demonstrate that LCHF diets cause minimal perturbations in glucose homeostasis and pancreatic β-cell activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.