ArticlePediatric research2013
Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Whole genome methylation and transcriptome analyses to identify risk for cerebral palsy (CP) in extremely low gestational age neonates (ELGAN).Scientific reports · 2021Trial
- Extreme prematurity: Risk and resiliency.Current problems in pediatric and adolescent health care · 2022Review
- Differential Gene Expression in Cord Blood of Infants Diagnosed with Cerebral Palsy: A Pilot Analysis of the Beneficial Effects of Antenatal Magnesium Cohort.Developmental neuroscience · 2022Article
- The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening.Frontiers in pediatrics · 2021Review
- Little to Give, Much to Gain-What Can You Do With a Dried Blood Spot?Current environmental health reports · 2020Review
- Dried Blood Spot RNA Transcriptomes Correlate with Transcriptomes Derived from Whole Blood RNA.The American journal of tropical medicine and hygiene · 2018Article
- Early Predictors and Correlates of Communication Function in Children With Cerebral Palsy.Journal of child neurology · 2018Article
- Article
- The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders.Molecular psychiatry · 2018Article
- Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation.Clinical epigenetics · 2018Article
- RNA sequencing of archived neonatal dried blood spots.Molecular genetics and metabolism reports · 2017Article
- Effect of storage time on gene expression data acquired from unfrozen archived newborn blood spots.Molecular genetics and metabolism · 2016Article
- Genome-Wide Profiling of RNA from Dried Blood Spots: Convergence with Bioinformatic Results Derived from Whole Venous Blood and Peripheral Blood Mononuclear Cells.Biodemography and social biology · 2016Article
- Article
- Comparison of frozen and unfrozen blood spots for gene expression studies.The Journal of pediatrics · 2014Article
- High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2013Article
- Reducing milking frequency during nutrient restriction has no effect on the hepatic transcriptome of lactating dairy cattle.Physiological genomics · 2013Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundGene expression in archived newborn blood spots remaining from newborn screening may reflect pathophysiological disturbances useful in understanding the etiology of cerebral palsy (CP).
methodsWe quantified the expression of gene sets representing four physiological pathways hypothesized to contribute to CP in archived unfrozen residual newborn blood spot specimens from 53 children with CP and 53 age-, gender-, and gestational age-matched controls. We selected four empirical and three canonical gene sets representing the inflammatory, hypoxic, coagulative, and thyroidal pathways and examined mRNA expression using an 8 × 60,000 oligonucleotide microarray. The log2 fold change of gene expression between matched cases and controls was analyzed using the generally applicable gene set enrichment method.
resultsThe empirical inflammatory and empirical hypoxic gene sets were significantly downregulated in term-born CP cases (n = 33) as compared with matched controls (P = 0.0007 and 0.0009, respectively), whereas both gene sets were significantly upregulated (P =0.0055 and 0.0223, respectively) in preterm-born CP cases (n = 20). The empirical thyroidal gene set was significantly upregulated in preterm-born CP cases (P = 0.0023).
conclusionThe newborn blood spot transcriptome can serve as a platform for investigating distinctive gene expression patterns in children who later develop CP.
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