ArticleBehavioural pharmacology2013
Impaired conditioned fear response and startle reactivity in epinephrine-deficient mice.
Article in Behavioural pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Fear expression is suppressed by tyrosine administration.Scientific reports · 2019Trial
- Glucose may Contribute to Retrieval and Reconsolidation of Contextual Fear Memory Through Hippocampal Nr4a3 and Bdnf mRNA Expression and May Act Synergically with Adrenaline.Molecular neurobiology · 2024Article
- Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy.NPJ Parkinson's disease · 2023Article
- Molecular pathways underlying sympathetic autonomic overshooting leading to fear and traumatic memories: looking for alternative therapeutic options for post-traumatic stress disorder.Frontiers in molecular neuroscience · 2023Review
- Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice.Neuropharmacology · 2021Article
- The acidified drinking water-induced changes in the behavior and gut microbiota of wild-type mice depend on the acidification mode.Scientific reports · 2021Article
- Treatment With Nepicastat Decreases Contextual Traumatic Memories Persistence in Post-traumatic Stress Disorder.Frontiers in molecular neuroscience · 2021Article
- Withdrawal Effects Following Methionine Exposure in Adult Zebrafish.Molecular neurobiology · 2020Article
- PhenylethanolaminePharmacogenomics · 2020Article
- Epinephrine May Contribute to the Persistence of Traumatic Memories in a Post-traumatic Stress Disorder Animal Model.Frontiers in molecular neuroscience · 2020Article
- Noradrenergic Modulation of Fear Conditioning and Extinction.Frontiers in behavioral neuroscience · 2018Review
- Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression ofFrontiers in molecular neuroscience · 2018Article
- Effects of oxytocin on background anxiety in rats with high or low baseline startle.Psychopharmacology · 2016Article
- Epinephrine increases contextual learning through activation of peripheral β2-adrenoceptors.Psychopharmacology · 2016Article
- Catecholaminergic based therapies for functional recovery after TBI.Brain research · 2016Review
- Fast cerebellar reflex circuitry requires synaptic vesicle priming by munc13-3.Cerebellum (London, England) · 2015Article
- Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating.Psychoneuroendocrinology · 2015Article
- Highly Expressed Genes within Hippocampal Sector CA1: Implications for the Physiology of Memory.Neurology international · 2014Article
- Superior pattern processing is the essence of the evolved human brain.Frontiers in neuroscience · 2014Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Norepinephrine and epinephrine signaling is thought to facilitate cognitive processes related to emotional events and heightened arousal; however, the specific role of epinephrine in these processes is less known. To investigate the selective impact of epinephrine on arousal and fear-related memory retrieval, mice unable to synthesize epinephrine (phenylethanolamine N-methyltransferase knockout, PNMT-KO) were tested for contextual and cued-fear conditioning. To assess the role of epinephrine in other cognitive and arousal-based behaviors these mice were also tested for acoustic startle, prepulse inhibition, novel object recognition, and open-field activity. Our results show that compared with wild-type mice, PNMT-KO mice showed reduced contextual fear but normal cued fear. Mice exhibited normal memory performance in the short-term version of the novel object recognition task, suggesting that PNMT mice exhibit more selective memory effects on highly emotional and/or long-term memories. Similarly, open-field activity was unaffected by epinephrine deficiency, suggesting that differences in freezing are not related to changes in overall anxiety or exploratory drive. Startle reactivity to acoustic pulses was reduced in PNMT-KO mice, whereas prepulse inhibition was increased. These findings provide further evidence for a selective role of epinephrine in contextual-fear learning and support its potential role in acoustic startle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.