ArticleGenome biology2012
Differential analysis of high-throughput quantitative genetic interaction data.
Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- A Normalization Protocol Reduces Edge Effect in High-Throughput Analyses of Hydroxyurea Hypersensitivity in Fission Yeast.Biomedicines · 2023Article
- Environmental robustness of the global yeast genetic interaction network.Science (New York, N.Y.) · 2021Article
- LI Detector: a framework for sensitive colony-based screens regardless of the distribution of fitness effects.G3 (Bethesda, Md.) · 2021Article
- Article
- Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping.Molecular cell · 2018Article
- Modeling heterogeneity in the pluripotent state: A promising strategy for improving the efficiency and fidelity of stem cell differentiation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Diffany: an ontology-driven framework to infer, visualise and analyse differential molecular networks.BMC bioinformatics · 2016Article
- Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.Oncotarget · 2015Article
- gitter: a robust and accurate method for quantification of colony sizes from plate images.G3 (Bethesda, Md.) · 2014Article
- Article
- A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.Cell reports · 2013Article
- SGAtools: one-stop analysis and visualization of array-based genetic interaction screens.Nucleic acids research · 2013Article
- Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Synthetic genetic arrays have been very effective at measuring genetic interactions in yeast in a high-throughput manner and recently have been expanded to measure quantitative changes in interaction, termed 'differential interactions', across multiple conditions. Here, we present a strategy that leverages statistical information from the experimental design to produce a novel, quantitative differential interaction score, which performs favorably compared to previous differential scores. We also discuss the added utility of differential genetic-similarity in differential network analysis. Our approach is preferred for differential network analysis, and our implementation, written in MATLAB, can be found at http://chianti.ucsd.edu/~gbean/compute_differential_scores.m.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.