Evidence map›Paper›PMID 23268719›Full record

ArticleJournal of natural products2013

Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth.

Krishna P Devkota, Jennifer Wilson, Curtis J Henrich, James B McMahon, Karlyne M Reilly, John A Beutler

Abstract read
In one paragraph

Article in Journal of natural products, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Alkamides inInternational journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Hydroxy-γ-sanshool fromFrontiers in nutrition · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Krishna P DevkotaMolecular Targets Laboratory, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.
Jennifer Wilson
Curtis J Henrich
James B McMahon
Karlyne M Reilly
John A Beutler

Funding

Molecular Targets ProgramZICBC010469 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OKEEFE, BARRY · 2009 to 2018
$31.4M
Building Libraries with Chemical Diversity for ScreeningZIABC011469 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
Development of Natural Product Leads as Anticancer TherapeuticsZIABC011470 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
Development of Mouse Neurofibromatosis Model for Preclinical TestingZIABC010541 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI REILLY, KARLYNE M · 2009 to 2014
$898k
CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011469Intramural NIH HHS ZIA BC011470NCI NIH HHS HHSN261200800001ENCI NIH HHS Y99 CA999999NIH HHS OD-Y2-OD-1557-01
6 · The paper itself

Abstract

A neurofibromatosis type 1 (NF1)-based bioassay-guided phytochemical investigation on Zanthoxylum armatum collected in Nepal led to the isolation of new timuramides A-D (1-4) and six known sanshools (5-10). The structures of all compounds were established by using modern spectroscopic techniques, including 1D and 2D NMR analysis and comparison with previously reported data. Most of the compounds inhibited growth of an Nf1- and p53-deficient mouse glioma cell line at noncytotoxic concentrations.

Indexed as

AnimalsHumansHydroxamic AcidsMiceMolecular StructureNepalNeurofibromatosis 1Nuclear Magnetic Resonance, BiomolecularTumor Suppressor Protein p53ZanthoxylumHydroxamic AcidsTumor Suppressor Protein p53

Identifiers

PMID23268719
PMCPMC3556213

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.