Evidence map›Paper›PMID 23268227›Full record

ReviewNature reviews. Microbiology2013

Bacteriocins - a viable alternative to antibiotics?

Paul D Cotter, R Paul Ross, Colin Hill

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 794 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
794citing papers in PubMed, 1 pooled it
87.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

794 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,752 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
  5. Review
  6. Article
  7. Review
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  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. F-Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  15. Probing theRSC chemical biology · 2026
    Article
  16. Bacteriocin production byRSC advances · 2026
    Article
  17. Article
  18. Pacin, a novel bacteriocin fromMicrobiology spectrum · 2026
    Article
  19. Review
  20. Review

734 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Paul D CotterTeagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland. paul.cotter@teagasc.ie
R Paul Ross
Colin Hill
Alimentary Health (Ireland) · IETeagasc - The Irish Agriculture and Food Development Authority · IEUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain bacteria, might warrant serious consideration as alternatives to traditional antibiotics. These molecules exhibit significant potency against other bacteria (including antibiotic-resistant strains), are stable and can have narrow or broad activity spectra. Bacteriocins can even be produced in situ in the gut by probiotic bacteria to combat intestinal infections. Although the application of specific bacteriocins might be curtailed by the development of resistance, an understanding of the mechanisms by which such resistance could emerge will enable researchers to develop strategies to minimize this potential problem.

Indexed as

Anti-Bacterial AgentsBacteriaBacteriocinsDrug Resistance, BacterialAnti-Bacterial AgentsBacteriocins

Identifiers

PMID23268227
OpenAlexW1544835748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.