ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2013
Serrated colon polyps as precursors to colorectal cancer.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Pooled it
- Determinants of high sessile serrated lesion detection: Role of faecal occult blood test and colonoscopy quality indicators.World journal of gastrointestinal endoscopy · 2025Trial
- Impact of an Endoscopic Quality Improvement Program Focused on Adenoma Detection on Sessile Serrated Adenoma/Polyp Detection.Digestive diseases and sciences · 2017Trial
- Detection rates of premalignant polyps during screening colonoscopy: time to revise quality standards?Gastrointestinal endoscopy · 2015Trial
- Multicomponent Lifestyle Interventions During Colorectal Cancer Surveillance: A Systematic Review.Cancers · 2026Review
- Investigating the expression of CTLA-4 and CD28 genes as immune regulators in patients with colorectal polyps.BMC cancer · 2026Article
- Diagnostic Yield of Fecal Immunochemical Test for Advanced Colorectal Neoplasms in Adults Under 50: A Single-Center Cohort in Taiwan.Journal of clinical medicine · 2026Article
- Role of CDX2 in the prognosis of colorectal cancer across stages 0-IV.Oncology letters · 2026Article
- Colorectal cancer sidedness: prognostic implications and the predictive role of artificial intelligence.BMC medical informatics and decision making · 2026Article
- Key genes and pathway differences between serrated polyps and conventional adenomas: insights from multi-omics.Translational cancer research · 2026Article
- Colonoscopy Quality Indicators in Transition: From Adenoma Detection Rate to Serrated Lesion Detection and Beyond.Diagnostics (Basel, Switzerland) · 2026Review
- Association between metabolic obesity phenotypes and risk of colorectal neoplasia in a south Australian surveillance colonoscopy population.Preventive medicine reports · 2026Article
- Metabolic factors are associated with a higher risk of conventional adenoma in males during surveillance colonoscopy: findings from a South Australian cohort.Scientific reports · 2025Article
- Serrated polyps in colorectal cancer prevention: prevalence, characteristics and clinical insights from a large retrospective cohort study.BMC gastroenterology · 2025Article
- Article
- Fecal Immunochemical Test Screening and Risk of Colorectal Cancer Death.JAMA network open · 2024Article
- Serrated polyposis syndrome: defining the epidemiology and predicting the risk of dysplasia.BMC gastroenterology · 2024Article
- Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway.Journal of gastroenterology · 2024Article
- Clinicopathologic and endoscopic features of sessile serrated lesions and conventional adenomas: a large inpatient population-based study in China.Frontiers in oncology · 2024Article
- Interval post-colonoscopy colorectal cancer following a negative colonoscopy in a fecal immunochemical test-based screening program.Endoscopy · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Identification of the serrated neoplasia pathway has improved our understanding of the pathogenesis of colorectal cancer (CRC). Insights include an increased recognition of the malignant potential of different types of serrated polyps such as sessile and traditional serrated adenomas. Sessile serrated adenomas share molecular features with colon tumors that have microsatellite instability and a methylator phenotype, indicating that these lesions are precursors that progress via the serrated neoplasia pathway. These data have important implications for clinical practice and CRC prevention, because hyperplastic polyps were previously regarded as having no malignant potential. There is also evidence that the serrated pathway contributes to interval or missed cancers. Endoscopic detection of serrated polyps is a challenge because they are often inconspicuous with indistinct margins and are frequently covered by adherent mucus. It is important for gastroenterologists to recognize the subtle endoscopic features of serrated polyps to facilitate their detection and removal, and thereby ensure a high-quality colonoscopic examination. Recognition of the role of serrated polyps in colon carcinogenesis has led to the inclusion of these lesions in postpolypectomy surveillance guidelines. However, an enhanced effort is needed to identify and completely remove serrated adenomas, with the goal of increasing the effectiveness of colonoscopy to reduce CRC incidence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.