ArticleBiomaterials2013
Mechanically induced intercellular calcium communication in confined endothelial structures.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Expanded applications of bioluminescence microscopy with phasor analysis.Cell reports methods · 2026Article
- Photothermally Powered 3D Microgels Mechanically Regulate Mesenchymal Stem Cells Under Anisotropic Force.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Mechanical Modulation, Physiological Roles, and Imaging Innovations of Intercellular Calcium Waves in Living Systems.Cancers · 2025Review
- Complement MASP-1 Modifies Endothelial Wound Healing.International journal of molecular sciences · 2024Article
- Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance.Nature communications · 2024Article
- Intercellular Calcium Waves and Permeability Change Induced by Vertically Deployed Surface Acoustic Waves in a Human Cerebral Microvascular Endothelial Cell Line (hCMEC/D3) Monolayer.Ultrasound in medicine & biology · 2023Article
- Intercellular water exchanges trigger soliton-like waves in multicellular systems.Biophysical journal · 2022Article
- Cataract Progression Associated with Modifications in Calcium Signaling in Human Lens Epithelia as Studied by Mechanical Stimulation.Life (Basel, Switzerland) · 2021Article
- Intercellular Bridge Mediates CaBiophysical journal · 2020Article
- Article
- Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.PLoS computational biology · 2016Article
- Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement.Scientific reports · 2016Article
- Concurrent shear stress and chemical stimulation of mechano-sensitive cells by discontinuous dielectrophoresis.Biomicrofluidics · 2016Article
- Critical waves and the length problem of biology.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers.Journal of cell science · 2015Article
- Probing mechanoregulation of neuronal differentiation by plasma lithography patterned elastomeric substrates.Scientific reports · 2014Article
- Single cell gene expression analysis in injury-induced collective cell migration.Integrative biology : quantitative biosciences from nano to macro · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Calcium signaling in the diverse vascular structures is regulated by a wide range of mechanical and biochemical factors to maintain essential physiological functions of the vasculature. To properly transmit information, the intercellular calcium communication mechanism must be robust against various conditions in the cellular microenvironment. Using plasma lithography geometric confinement, we investigate mechanically induced calcium wave propagation in networks of human umbilical vein endothelial cells organized. Endothelial cell networks with confined architectures were stimulated at the single cell level, including using capacitive force probes. Calcium wave propagation in the network was observed using fluorescence calcium imaging. We show that mechanically induced calcium signaling in the endothelial networks is dynamically regulated against a wide range of probing forces and repeated stimulations. The calcium wave is able to propagate consistently in various dimensions from monolayers to individual cell chains, and in different topologies from linear patterns to cell junctions. Our results reveal that calcium signaling provides a robust mechanism for cell-cell communication in networks of endothelial cells despite the diversity of the microenvironmental inputs and complexity of vascular structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.