ArticleBMC medical genomics2012
Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study.
Article in BMC medical genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis.Clinics (Sao Paulo, Brazil) · 2019Pooled it
- Association of the IL-13 polymorphisms rs1800925 and rs20541 with chronic obstructive pulmonary disease risk: An updated meta-analysis.Medicine · 2017Pooled it
- Association between theBioscience reports · 2017Pooled it
- Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive pulmonary disease: a meta-analysis.Molecular biology reports · 2014Pooled it
- Pooled it
- Association ofAnnals of medicine · 2025Article
- Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease.Respiratory research · 2025Article
- Article
- Hedgehog signaling modulates cigarette-induced COPD development.Experimental and therapeutic medicine · 2021Article
- The AGE-RAGE Axis and RAGE Genetics in Chronic Obstructive Pulmonary Disease.Clinical reviews in allergy & immunology · 2021Review
- Comparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population.Journal of translational medicine · 2020Article
- Genetic underpinnings of lung function and COPD.Journal of genetics · 2019Review
- Association ofAging · 2019Article
- Pathological Implications of Receptor for Advanced Glycation End-Product (Disease markers · 2019Review
- Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis.Frontiers in immunology · 2018Article
- Novel aspects of pathogenesis and regeneration mechanisms in COPD.International journal of chronic obstructive pulmonary disease · 2015Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. Few gene studies of the Chinese population have focused on COPD. We investigated candidate genes associated with susceptibility to COPD in the Chinese Han population.
methodsA total of 331 COPD patients and 213 control subjects were recruited for this study. Nighty-seven single-nucleotide polymorphisms (SNPs) of 46 genes were selected for genotyping. Genotypes were determined using multiplex polymerase chain reaction (PCR).
resultsSignificant differences between patients and healthy controls were observed in the allele frequencies of seven SNPs: rs1205 C, rs2353397 C, rs20541 T, rs2070600 G, rs10947233 G, rs1800629 G, and rs2241712 A. After Bonferroni correction, rs2353397 C was most strongly associated with susceptibility to COPD. Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).
conclusionOur study suggests some genetic variants associated with the susceptibility of COPD in the Chinese Han population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.