ArticleBioorganic & medicinal chemistry2013
Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions.
Article in Bioorganic & medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- From Concepts to Inhibitors: A Blueprint for Targeting Protein-Protein Interactions.Chemical reviews · 2025Review
- Variation in predicted COVID-19 risk among lemurs and lorises.American journal of primatology · 2021Article
- Peptide-based inhibitors of protein-protein interactions: biophysical, structural and cellular consequences of introducing a constraint.Chemical science · 2021Review
- Variation in predicted COVID-19 risk among lemurs and lorises.bioRxiv : the preprint server for biology · 2021Article
- Comparative ACE2 variation and primate COVID-19 risk.Communications biology · 2020Article
- Comparative ACE2 variation and primate COVID-19 risk.bioRxiv : the preprint server for biology · 2020Article
- The design and development of covalent protein-protein interaction inhibitors for cancer treatment.Journal of hematology & oncology · 2020Review
- Detection of the in vitro modulation of Plasmodium falciparum Arf1 by Sec7 and ArfGAP domains using a colorimetric plate-based assay.Scientific reports · 2020Article
- Investigation and Prediction of Human Interactome Based on Quantitative Features.Frontiers in bioengineering and biotechnology · 2020Article
- Review
- The oncogenic potential of small nuclear ribonucleoprotein polypeptide G: a comprehensive and perspective view.American journal of translational research · 2019Review
- Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein⁻Protein Interactions.Molecules (Basel, Switzerland) · 2018Review
- RNA Polymerase Tags To Monitor Multidimensional Protein-Protein Interactions Reveal Pharmacological Engagement of Bcl-2 Proteins.Journal of the American Chemical Society · 2017Article
- Protein Domain Mimics as Modulators of Protein-Protein Interactions.Accounts of chemical research · 2017Review
- Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.ACS medicinal chemistry letters · 2017Article
- Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1.ChemMedChem · 2016Review
- New Frontiers in Druggability.Journal of medicinal chemistry · 2015Article
- Alternative modulation of protein-protein interactions by small molecules.Current opinion in biotechnology · 2015Review
- High-resolution structures of a heterochiral coiled coil.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability.Chemical science · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Development of specific ligands for protein targets that help decode the complexities of protein-protein interaction networks is a key goal for the field of chemical biology. Despite the emergence of powerful in silico and experimental high-throughput screening strategies, the discovery of synthetic ligands that selectively modulate protein-protein interactions remains a challenge for bioorganic and medicinal chemists. This Perspective discusses emerging principles for the rational design of PPI inhibitors. Fundamentally, the approach seeks to adapt nature's protein recognition principles for the design of suitable secondary structure mimetics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.