ArticleBMC evolutionary biology2012
Evolution of cichlid vision via trans-regulatory divergence.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Evolution of miRNA-Binding Sites and Regulatory Networks in Cichlids.Molecular biology and evolution · 2022Article
- Axes of visual adaptation in the ecologically diverse family Cichlidae.Seminars in cell & developmental biology · 2020Review
- Tbx2a Modulates Switching of RH2 and LWS Opsin Gene Expression.Molecular biology and evolution · 2020Article
- Diurnal variation in opsin expression and common housekeeping genes necessitates comprehensive normalization methods for quantitative real-time PCR analyses.Molecular ecology resources · 2019Article
- Conservation and novelty in the microRNA genomic landscape of hyperdiverse cichlid fishes.Scientific reports · 2019Article
- Integrating transcriptomic network reconstruction and eQTL analyses reveals mechanistic connections between genomic architecture and Brassica rapa development.PLoS genetics · 2019Article
- Multiple trans QTL and one cis-regulatory deletion are associated with the differential expression of cone opsins in African cichlids.BMC genomics · 2018Article
- The Evolution of Gene Expression in cis and trans.Trends in genetics : TIG · 2018Review
- Adult plasticity in African cichlids: Rapid changes in opsin expression in response to environmental light differences.Molecular ecology · 2017Article
- Determination of the Genetic Architecture Underlying Short Wavelength Sensitivity in Lake Malawi Cichlids.The Journal of heredity · 2017Article
- Retinal specialization through spatially varying cell densities and opsin coexpression in cichlid fish.The Journal of experimental biology · 2017Article
- Exploring visual plasticity: dietary carotenoids can change color vision in guppies (Poecilia reticulata).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Proximate and ultimate causes of variable visual sensitivities: Insights from cichlid fish radiations.Genesis (New York, N.Y. : 2000) · 2016Review
- Sensory modalities in cichlid fish behavior.Current opinion in behavioral sciences · 2015Article
- QTL clustering as a mechanism for rapid multi-trait evolution.Communicative & integrative biology · 2013Article
- Quantitative genetic analysis of retinal degeneration in the blind cavefish Astyanax mexicanus.PloS one · 2013Article
- Colour variation in cichlid fish: developmental mechanisms, selective pressures and evolutionary consequences.Seminars in cell & developmental biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPhenotypic evolution may occur through mutations that affect either the structure or expression of protein-coding genes. Although the evolution of color vision has historically been attributed to structural mutations within the opsin genes, recent research has shown that opsin regulatory mutations can also tune photoreceptor sensitivity and color vision. Visual sensitivity in African cichlid fishes varies as a result of the differential expression of seven opsin genes. We crossed cichlid species that express different opsin gene sets and scanned their genome for expression Quantitative Trait Loci (eQTL) responsible for these differences. Our results shed light on the role that different structural, cis-, and trans-regulatory mutations play in the evolution of color vision.
resultsWe identified 11 eQTL that contribute to the divergent expression of five opsin genes. On three linkage groups, several eQTL formed regulatory "hotspots" associated with the expression of multiple opsins. Importantly, however, the majority of the eQTL we identified (8/11 or 73%) occur on linkage groups located trans to the opsin genes, suggesting that cichlid color vision has evolved primarily via trans-regulatory divergence. By modeling the impact of just two of these trans-regulatory eQTL, we show that opsin regulatory mutations can alter cichlid photoreceptor sensitivity and color vision at least as much as opsin structural mutations can.
conclusionsCombined with previous work, we demonstrate that the evolution of cichlid color vision results from the interplay of structural, cis-, and especially trans-regulatory loci. Although there are numerous examples of structural and cis-regulatory mutations that contribute to phenotypic evolution, our results suggest that trans-regulatory mutations could contribute to phenotypic divergence more commonly than previously expected, especially in systems like color vision, where compensatory changes in the expression of multiple genes are required in order to produce functional phenotypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.