ArticleDeutsches Arzteblatt international2012
The impact of arterial hypertension on polytrauma and traumatic brain injury.
Article in Deutsches Arzteblatt international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Resuscitative endovascular occlusion of the aorta restores cerebral metabolic markers of ischaemia induced by haemorrhagic shock.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Cerebral glycerol during haemorrhagic shock in normal and raised intracranial pressure resuscitated with total REBOA: an experimental porcine study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Impact of Prehospital Blood Pressure Profile on Functional Outcome After Traumatic Brain Injury.Journal of clinical medicine · 2025Article
- Article
- Cerebral haemodynamics and intracranial pressure during haemorrhagic shock and resuscitation with total endovascular balloon occlusion of the aorta in an animal model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- The predictive value of the Kampala Trauma Score (KTS) in the outcome of multi-traumatic patients compared to the estimated Injury Severity Score (eISS).BMC emergency medicine · 2024Article
- Identification of clinically relevant patient endotypes in traumatic brain injury using latent class analysis.Scientific reports · 2024Article
- Critical hypertension in trauma patients following prehospital emergency anaesthesia: a multi-centre retrospective observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023Observational
- Expert consensus on blood pressure management in critically ill patients.Journal of intensive medicine · 2023Article
- Cannabidiol Reduces Short- and Long-Term High Glutamate Release after Severe Traumatic Brain Injury and Improves Functional Recovery.Pharmaceutics · 2022Article
- Article
- Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide.International journal of molecular sciences · 2021Review
- Does hypertension at initial presentation adversely affect outcomes in pediatric traumatic brain injury?Journal of pediatric surgery · 2020Observational
- Traumatic brain injury may worsen clinical outcomes after prolonged partial resuscitative endovascular balloon occlusion of the aorta in severe hemorrhagic shock model.The journal of trauma and acute care surgery · 2019Article
- Changes in anaesthetic use for trauma patients in German HEMS - a retrospective study over a ten-year period.Scandinavian journal of trauma, resuscitation and emergency medicine · 2019Article
- Hypertension After Severe Traumatic Brain Injury: Friend or Foe?Journal of neurosurgical anesthesiology · 2017Review
- The effect of resuscitative endovascular balloon occlusion of the aorta, partial aortic occlusion and aggressive blood transfusion on traumatic brain injury in a swine multiple injuries model.The journal of trauma and acute care surgery · 2017Article
- Role of Interleukin-10 in Acute Brain Injuries.Frontiers in neurology · 2017Review
- Significant modification of traditional rapid sequence induction improves safety and effectiveness of pre-hospital trauma anaesthesia.Critical care (London, England) · 2015Article
- Blood pressure regulation to prevent progression of blunt traumatic intracranial hemorrhage in stable patients.Neurocritical care · 2014Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-hospital hypotension in trauma patients is associated with high mortality. Especially for patients with severe traumatic brain injury (TBI), arterial normotension or even hypertension (AHT) is considered an important mechanism for sustaining adequate cerebral perfusion pressure. The effect of pre-hospital arterial hypertension (pAHT) on in-hospital mortality after trauma has not been studied to date.
methodsWe retrospectively analyzed data in the trauma registry of the German Society for Trauma Surgery (DGU) on all trauma patients in Germany from 1993 to 2008 who were 16 to 80 years old at the time of the trauma and had an injury severity score (ISS) of 9 or above (total, 42 500 patient data sets). For the analysis, we divided the patients into two groups: those with and those without TBI. We further divided the TBI patients into five subgroups depending on the course of their systolic blood pressure up to the moment of their arrival at the hospital. We also analyzed the patients' demographic data, patterns of injury, and accident mechanisms.
resultsTrauma patients with TBI and pAHT (142 of 561 patients) had a significantly higher mortality than normotensive TBI patients (25.3% vs. 13.5%, p<0.001). Arterial hypertension that either rises or falls before the patient reaches the hospital is associated with higher in-hospital mortality. A logistical regression analysis of 5384 patients revealed that patients with pAHT (n = 561) had an odds ratio of 1.9 (95% confidence interval, 1.4 to 1.6) for death in the hospital compared to normotensive patients (n = 6020).
conclusionSystolic blood pressure values above 160 mm Hg before arrival in the hospital worsen the outcome of trauma patients with TBI.
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