ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2012
Helicobacter pylori in Iran: A systematic review on the association of genotypes and gastroduodenal diseases.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis.BMC gastroenterology · 2020Pooled it
- Association of Helicobacter Pylori with Presence of Myocardial Infarction in Iran: A Systematic Review and Meta-Analysis.Ethiopian journal of health sciences · 2017Pooled it
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- A review for non-antibiotic treatment ofFrontiers in microbiology · 2024Review
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- Prevalence ofMiddle East journal of digestive diseases · 2021Article
- Expression Profile of miRNA-17-3p and miRNA-17-5p Genes in Gastric Cancer Patients with Helicobacter pylori Infection.Journal of gastrointestinal cancer · 2021Observational
- Clinical and laboratory importance of detectingPrzeglad gastroenterologiczny · 2020Review
- Reflex Gastroesophageal Disorders and Functional Dyspepsia: Potential Confounding Variables for the Progression of Chronic Periodontitis: A Clinical Study.International journal of preventive medicine · 2020Article
- Determination of optimal time for reading of rapid urease test diagnosis ofGastroenterology and hepatology from bed to bench · 2020Article
- High Prevalence of Antibiotic Resistance in IranianJournal of clinical medicine · 2019Article
- Value of CIM, CLO Test and Multiplex PCR for the Diagnosis of Helicobacter Pylori Infection Status in Patients with Gastritis and Gastric Ulcer.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- The Interaction ofAdvanced biomedical research · 2019Review
- The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency inBioMed research international · 2019Article
- Association ofMedical journal of the Islamic Republic of Iran · 2018Article
- Determination ofMedical journal of the Islamic Republic of Iran · 2017Article
- The Association between Oral Hygiene and Gastric Pathology in Patients with Dyspepsia: a Cross-Sectional Study in Southeast Iran.Middle East journal of digestive diseases · 2017Article
- Economic evaluation of test-and-treat and empirical treatment strategies in the eradication of Helicobacter pylori infection; A Markov model in an Iranian adult population.Medical journal of the Islamic Republic of Iran · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori (H. pylori) infection is known as a major etiologic factor for a variety of gastroduodenal diseases. In Iran, with a high rate of H. pylori infection close to 90%, numerous studies have revealed many aspects of interaction between the bacterium, mucosal surface and induction of disease outcome. The organism is genetically diverse and several virulence factors are attributed to the more virulent strains. The well-characterized virulence factors of H. pylori are cytotoxin associated gene A and vacuolating cytotoxin gene A. The distribution pattern of H. pylori genotypes and its association with disease status varies geographically. The present review focused on the virulence factors and genotyping of H. pylori in relation to gastroduodenal disorders in different regions of Iran.
methodsIn total, 398 studies were reported on different aspects related to H. pylori in our electronic search from 1995-2011. H. pylori infection and its virulence factors in association with disease status were investigated in 159 reports. Looking specifically at the gastrointestinal tract disorders, the most relevant reports including 37 papers were selected.
resultsWe found no correlation of cagA genotype and disease status in the majority of studies, whereas vacA was demonstrated as a useful marker in predicting the disease outcome. The results of reports on other virulence factors of H. pylori such as blood group antigen-binding adhesion gene A, the induced by contact with epithelium gene A, the outer inflammatory protein A, the duodenal ulcer promoting gene A, and Helicobacter outer membrane gene and their relation with disease status were contradictory.
conclusionsAlthough different markers of H. pylori were emphasized as useful when predicting disease outcomes in some studies, the inconsistent researches and the scarcity of data made any conclusion or even comparison impossible. Considering the gap of information observed during our search relating to genotyping and other aspects of H. pylori infection, further investigations are suggested.
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23267382PMC3527048W1909305303What OpenQuestion holds
Registered trials
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