ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2012
Comparison of the metabolic parameters and androgen level of umbilical cord blood in newborns of mothers with polycystic ovary syndrome and controls.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Systematic review and meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome.Nature communications · 2024Pooled it
- Systematic review and meta-analysis of birth outcomes in women with polycystic ovary syndrome.Nature communications · 2024Pooled it
- Androgen levels in the fetal cord blood of children born to women with polycystic ovary syndrome: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2020Pooled it
- Metabolic reprogramming in placenta and umbilical cord serum of polycystic ovary syndrome pregnancies: testosterone-associated alterations and interaction with obesity.Human reproduction open · 2026Article
- Chinese herbal medicine on the offspring of women with polycystic ovary syndrome: A retrospective cohort study.Medicine · 2025Article
- Integrated Transcriptome Analysis of lncRNA, miRNA, and mRNA Reveals key Regulatory Modules for Polycystic Ovary Syndrome.Phenomics (Cham, Switzerland) · 2024Article
- Preconceptional maternal hyperandrogenism and metabolic syndrome risk in male offspring: a long-term population-based study.Journal of endocrinological investigation · 2024Article
- Review
- Growth Restriction in the Offspring of Mothers With Polycystic Ovary Syndrome.JAMA network open · 2024Article
- Changes in circulating forms of anti-Muüllerian hormone and androgens in women with and without PCOS: a systematic longitudinal study throughout pregnancy.Human reproduction (Oxford, England) · 2023Article
- Maternal hyperandrogenism is associated with a higher risk of type 2 diabetes mellitus and overweight in adolescent and adult female offspring: a long-term population-based follow-up study.Journal of endocrinological investigation · 2022Article
- Endocrine and metabolic interactions in healthy pregnancies and hyperinsulinemic pregnancies affected by polycystic ovary syndrome, diabetes and obesity.Frontiers in endocrinology · 2022Review
- Metabolic parameters in cord blood of neonate of mothers with obese and non-obese PCOS and controls: retrospective cohort study.BMC pregnancy and childbirth · 2021Article
- An association between body image dissatisfaction and digit ratio among Chinese children and adolescents.Scientific reports · 2021Article
- Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development.The Journal of steroid biochemistry and molecular biology · 2021Article
- Mechanisms of intergenerational transmission of polycystic ovary syndrome.Reproduction (Cambridge, England) · 2020Review
- A Narrative Review of Placental Contribution to Adverse Pregnancy Outcomes in Women With Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2019Review
- Androgens in maternal vascular and placental function: implications for preeclampsia pathogenesisReproduction (Cambridge, England) · 2018Review
- Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain.European journal of endocrinology · 2017Article
- Effect of maternal PCOS and PCOS-like phenotype on the offspring's health.Molecular and cellular endocrinology · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to assess the metabolic parameters and androgen concentration in the cord blood of newborns of mothers with polycystic ovary syndrome (PCOS) in comparison with controls. MATERIALS AND
methodsThis cross-sectional study was conducted in 2010-2011 in Isfahan, Iran. Biochemical tests were conducted on 40 infants, born from singleton pregnancies in women with PCOS and an equal number of controls.
resultsThe mean weight gain during pregnancy was higher in women with PCOS than in controls (16.02 ± 4.39 vs. 9.10 ± 2.20 kg, respectively, P < 0.0001). The mean birth weight was lower in newborns of mothers with PCOS than in controls (2905.25 ± 415.59 vs. 3223.25 ± 425.02 vs. grams, respectively, P = 0.001). The mean testosterone was higher in cord blood of newborns of PCOS women than in controls (5.58 ± 3.20 vs. 2.28 ± 0.62 pg/ml, P < 0.0001). Triglycerides and LDL-C were lower in cord blood of newborns, born from PCOS women than in controls (P = 0.001). The birth weight of the newborns of PCOS mothers was negatively correlated to free testosterone of cord blood (R = -0. 26, P = 0.04).
conclusionThe metabolic aberration in PCOS might influence fetal birth weight and cord blood lipid profile. These disorders may be caused by an exposure to elevated testosterone level during fetal life. The offspring of PCOS women may be at higher risk for chronic diseases in later life. The clinical impact of our findings should be confirmed in future longitudinal studies.
Indexed as
Identifiers
23267369PMC3527035W1953483834What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.