ArticleFrontiers in endocrinology2012
Neuropeptide GPCRs in C. elegans.
Article in Frontiers in endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Non-Mammalian Models for Mitochondria Research in CNS Disorders.Biomolecules · 2026Review
- A neuropeptide regulates cell non-autonomous protein homeostasis.Cell reports · 2026Article
- Harnessing microbial tools: Escherichia coli as a vehicle for neuropeptide functional analysis in Caenorhabditis elegans.Genetics · 2026Article
- Transcriptional regulation of neuropeptide receptors underlies context-dependent adaptation in Drosophila melanogaster.FEBS open bio · 2026Article
- Nictation behavior in nematodes.BMC biology · 2025Review
- Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory.iScience · 2025Article
- GPCR Sense Communication Among Interaction Nematodes with Other Organisms.International journal of molecular sciences · 2025Review
- Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning.Cell genomics · 2024Article
- The genome of the simultaneously hermaphroditic snail Lymnaea stagnalis reveals an evolutionary expansion of FMRFamide-like receptors.Scientific reports · 2024Article
- Cell non-autonomous signaling through the conserved C. elegans glycoprotein hormone receptor FSHR-1 regulates cholinergic neurotransmission.PLoS genetics · 2024Article
- Neuropeptide and serotonin co-transmission sets the activity pattern in the C. elegans egg-laying circuit.Current biology : CB · 2024Article
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- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
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- Mitochondrial recovery by the UPRSeminars in cell & developmental biology · 2024Review
- Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis inbioRxiv : the preprint server for biology · 2024Article
- Rhodopsin orphan GPCR20 interacts with neuropeptides and directs growth, sexual differentiation, and egg production in femaleMicrobiology spectrum · 2024Article
25 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools. The availability of the worm's complete genome sequence allows researchers to browse through it, uncovering putative neuropeptides and their cognate G protein-coupled receptors (GPCRs). Many predictions have been made about the number of C. elegans neuropeptide GPCRs. In this review, we report the state of the art of both verified as well as predicted C. elegans neuropeptide GPCRs. The predicted neuropeptide GPCRs are incorporated into the receptor classification system based on their resemblance to orthologous GPCRs in insects and vertebrates. Appointing the natural ligand(s) to each predicted neuropeptide GPCR (receptor deorphanization) is a crucial step during characterization. The development of deorphanization strategies resulted in a significant increase in the knowledge of neuropeptidergic signaling in C. elegans. Complementary localization and functional studies demonstrate that neuropeptides and their GPCRs represent a rich potential source of behavioral variability in C. elegans. Here, we review all neuropeptidergic signaling pathways that so far have been functionally characterized in C. elegans.
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