ArticleFrontiers in computational neuroscience2012
Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity.
Article in Frontiers in computational neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Astrocyte-mediated higher-order control of synaptic plasticity.Communications biology · 2026Article
- The emerging role of astrocytes in spatial cognition, action and Alzheimer's disease.Frontiers in cellular neuroscience · 2026Review
- Postsynaptic frequency filters shaped by the interplay of synaptic short-term plasticity and cellular time scales.Journal of computational neuroscience · 2025Article
- Calcium Dynamics in Astrocyte-Neuron Communication from Intracellular to Extracellular Signaling.Cells · 2025Review
- The cost of unmodeled biological complexity in artificial neural networks.Patterns (New York, N.Y.) · 2025Review
- Astrocyte-mediated neuronal irregularities and dynamics: the complexity of the tripartite synapse.Biological cybernetics · 2024Article
- Persistence of post-stress blood pressure elevation requires activation of astrocytes.Scientific reports · 2024Article
- Network Bursts in 3D Neuron Clusters Cultured on Microcontact-Printed Substrates.Micromachines · 2023Article
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- Temporal filters in response to presynaptic spike trains: interplay of cellular, synaptic and short-term plasticity time scales.Journal of computational neuroscience · 2022Article
- Amyloid pathology disrupts gliotransmitter release in astrocytes.PLoS computational biology · 2022Article
- The glutamatergic synapse: a complex machinery for information processing.Cognitive neurodynamics · 2021Review
- Emulation of Astrocyte Induced Neural Phase Synchrony in Spin-Orbit Torque Oscillator Neurons.Frontiers in neuroscience · 2021Article
- Astrocytic Modulation of Neuronal Activity in the Suprachiasmatic Nucleus: Insights from Mathematical Modeling.Journal of biological rhythms · 2020Article
- On the Self-Repair Role of Astrocytes in STDP Enabled Unsupervised SNNs.Frontiers in neuroscience · 2020Article
- The brain as a "hyper-network": the key role of neural networks as main producers of the integrated brain actions especially via the "broadcasted" neuroconnectomics.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third Factor in Computational Models.Frontiers in computational neuroscience · 2018Review
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Challenges in Reproducibility, Replicability, and Comparability of Computational Models and Tools for Neuronal and Glial Networks, Cells, and Subcellular Structures.Frontiers in neuroinformatics · 2018Article
- Automated Functional Analysis of Astrocytes from Chronic Time-Lapse Calcium Imaging Data.Frontiers in neuroinformatics · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
The complexity of the signaling network that underlies astrocyte-synapse interactions may seem discouraging when tackled from a theoretical perspective. Computational modeling is challenged by the fact that many details remain hitherto unknown and conventional approaches to describe synaptic function are unsuitable to explain experimental observations when astrocytic signaling is taken into account. Supported by experimental evidence is the possibility that astrocytes perform genuine information processing by means of their calcium signaling and are players in the physiological setting of the basal tone of synaptic transmission. Here we consider the plausibility of this scenario from a theoretical perspective, focusing on the modulation of synaptic release probability by the astrocyte and its implications on synaptic plasticity. The analysis of the signaling pathways underlying such modulation refines our notion of tripartite synapse and has profound implications on our understanding of brain function.
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