ArticleProceedings of the National Academy of Sciences of the United States of America2013
Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of metabolomics biomarkers for Bisphenol A exposure.Metabolomics : Official journal of the Metabolomic Society · 2018Pooled it
- Review
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- Analysis of hepatic lentiviral vector transduction; implications for preclinical studies and clinical gene therapy protocols.bioRxiv : the preprint server for biology · 2024Article
- Epigenetic Reprogramming inCells · 2023Review
- Bisphenol-A reduces DNA methylation after metabolic activation.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2022Article
- Dietary Phytoestrogens and Their Metabolites as Epigenetic Modulators with Impact on Human Health.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Variably methylated retrotransposons are refractory to a range of environmental perturbations.Nature genetics · 2021Article
- Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood.Scientific reports · 2020Article
- Endocrine disruption of gene expression and microRNA profiles in hippocampus and hypothalamus of California mice: Association of gene expression changes with behavioural outcomes.Journal of neuroendocrinology · 2020Article
- Early genistein exposure of California mice and effects on the gut microbiota-brain axis.The Journal of endocrinology · 2019Article
- Association between gestational urinary bisphenol a concentrations and adiposity in young children: The MIREC study.Environmental research · 2019Article
- Effects of Phytoestrogens on the Developing Brain, Gut Microbiota, and Risk for Neurobehavioral Disorders.Frontiers in nutrition · 2019Review
- BPA and Nutraceuticals, Simultaneous Effects on Endocrine Functions.Endocrine, metabolic & immune disorders drug targets · 2019Review
- Insertion of a chimeric retrotransposon sequence in mouseMobile DNA · 2019Article
- Perinatal Bisphenol A Exposure Increases Atherosclerosis in Adult Male PXR-Humanized Mice.Endocrinology · 2018Article
- Gestational Exposure to Bisphenol A Affects the Function and Proteome Profile of F1 Spermatozoa in Adult Mice.Environmental health perspectives · 2017Article
- Environmentally induced epigenetic toxicity: potential public health concerns.Critical reviews in toxicology · 2016Review
- Minireview: Epigenomic Plasticity and Vulnerability to EDC Exposures.Molecular endocrinology (Baltimore, Md.) · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Reports that maternal diet influences coat color in mouse offspring carrying the agouti A(vy) allele have received considerable attention because the range, from pseudoagouti (brown) to yellow, predicts adult health outcomes, especially disposition toward obesity and diabetes, in yellower mice. Bisphenol A (BPA), an endocrine-disrupting compound with estrogenic properties, fed to a/a dams harboring A(vy)/a conceptuses has been reported to induce a significant shift toward yellower mice, whereas consumption of either genistein (G) alone or in combination with BPA led to greater numbers of healthy, brown offspring. Groups of C57/B6 a/a females, which are nonagouti, were fed either a phytoestrogen-free control diet or one of six experimental diets: diets 1-3 contained BPA (50 mg, 5 mg, and 50 μg BPA/kg food, respectively); diet 4 contained G (250 mg/kg food); diet 5 contained G plus BPA (250 and 50 mg/kg food, respectively); and diet 6 contained 0.1 μg of ethinyl estradiol (EE)/kg food. Mice were bred to A(vy)/a males over multiple parities. In all, 2,824 pups from 426 litters were born. None of the diets provided any significant differences in relative numbers of brown, yellow, or intermediate coat color A(vy)/a offspring. However, BPA plus G (P < 0.0001) and EE diets (P = 0.005), but not the four others, decreased the percentage of black (a/a) to A(vy)/a offspring from the expected Mendelian ratio of 1:1. Data suggest that A(vy)/a conceptuses, which may possess a so-called "thrifty genotype," are at a competitive advantage over a/a conceptuses in certain uterine environments.
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