Trial reportProceedings of the National Academy of Sciences of the United States of America2013
Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Diffuse reflectance spectroscopy for enhanced diagnostic precision in breast cancer.Journal of translational medicine · 2025Article
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Tunable Nanomaterials of Intracellular Crystallization for In Situ Biolabeling and Biomedical Imaging.Chemical & biomedical imaging · 2023Review
- Physicochemical understanding of biomineralization by molecular vibrational spectroscopy: From mechanism to nature.Exploration (Beijing, China) · 2023Review
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy.Biomedical optics express · 2023Article
- Diffuse reflectance spectroscopy for accurate margin assessment in breast-conserving surgeries: importance of an optimal number of fibers.Biomedical optics express · 2023Article
- Diffuse Reflectance Spectroscopy of the Oral Mucosa: In Vivo Experimental Validation of the Precancerous Lesions Early Detection Possibility.Diagnostics (Basel, Switzerland) · 2023Article
- VIS-NIR Diffuse Reflectance Spectroscopy System with Self-Calibrating Fiber-Optic Probe: Study of Perturbation Resistance.Diagnostics (Basel, Switzerland) · 2023Article
- Insights into Biochemical Sources and Diffuse Reflectance Spectral Features for Colorectal Cancer Detection and Localization.Cancers · 2022Article
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis.Theranostics · 2022Article
- Evaluation of wavelength ranges and tissue depth probed by diffuse reflectance spectroscopy for colorectal cancer detection.Scientific reports · 2021Article
- Optimizing algorithm development for tissue classification in colorectal cancer based on diffuse reflectance spectra.Biomedical optics express · 2019Article
- Tissue diagnosis during colorectal cancer surgery using optical sensing: an in vivo study.Journal of translational medicine · 2019Article
- Diffuse reflectance spectroscopy-enhanced drill for bone boundary detection.Biomedical optics express · 2019Article
- Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery.Journal of translational medicine · 2018Article
- Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps.Journal of biomedical optics · 2017Article
- Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning.Scientific reports · 2017Article
- A grid matrix-based Raman spectroscopic method to characterize different cell milieu in biopsied axillary sentinel lymph nodes of breast cancer patients.Lasers in medical science · 2016Article
- Label-free route to rapid, nanoscale characterization of cellular structure and dynamics through opaque media.Scientific reports · 2013Article
- Raman imaging at biological interfaces: applications in breast cancer diagnosis.Molecular cancer · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse reflectance spectroscopy for detection of microcalcifications that focuses on variations in optical absorption stemming from the calcified clusters and the associated cross-linking molecules. In this study, diffuse reflectance spectra are acquired ex vivo from 203 sites in fresh biopsy tissue cores from 23 patients undergoing stereotactic breast needle biopsies. By correlating the spectra with the corresponding radiographic and histologic assessment, we have developed a support vector machine-derived decision algorithm, which shows high diagnostic power (positive predictive value and negative predictive value of 97% and 88%, respectively) for diagnosis of lesions with microcalcifications. We further show that these results are robust and not due to any spurious correlations. We attribute our findings to the presence of proteins (such as elastin), and desmosine and isodesmosine cross-linkers in the microcalcifications. It is important to note that the performance of the diffuse reflectance decision algorithm is comparable to one derived from the corresponding Raman spectra, and the considerably higher intensity of the reflectance signal enables the detection of the targeted lesions in a fraction of the spectral acquisition time. Our findings create a unique landscape for spectroscopic validation of breast core needle biopsy for detection of microcalcifications that can substantially improve the likelihood of an adequate, diagnostic biopsy in the first attempt.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.