ArticleGenetics2013
The variance of identity-by-descent sharing in the Wright-Fisher model.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- When migration leaves a clean trace: Decoupling migration from coalescence in the structured serial coalescent.bioRxiv : the preprint server for biology · 2025Article
- Identity-by-descent segments in large samples.Theoretical population biology · 2025Article
- Accurate detection of identity-by-descent segments in human ancient DNA.Nature genetics · 2024Article
- On the origin and structure of haplotype blocks.Molecular ecology · 2023Article
- Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative.Genome medicine · 2022Article
- Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals.PLoS genetics · 2022Article
- Rapid detection of identity-by-descent tracts for mega-scale datasets.Nature communications · 2021Article
- Variance and limiting distribution of coalescence times in a diploid model of a consanguineous population.Theoretical population biology · 2021Article
- Current Developments in Detection of Identity-by-Descent Methods and Applications.Frontiers in genetics · 2021Review
- Variation in Genetic Relatedness Is Determined by the Aggregate Recombination Process.Genetics · 2020Article
- Article
- Estimating recent migration and population-size surfaces.PLoS genetics · 2019Article
- The time and place of European admixture in Ashkenazi Jewish history.PLoS genetics · 2017Article
- Article
- IBD Sharing between Africans, Neandertals, and Denisovans.Genome biology and evolution · 2016Article
- Explosive genetic evidence for explosive human population growth.Current opinion in genetics & development · 2016Review
- Rapidly Registering Identity-by-Descent Across Ancestral Recombination Graphs.Journal of computational biology : a journal of computational molecular cell biology · 2016Article
- Atlas of Cryptic Genetic Relatedness Among 1000 Human Genomes.Genome biology and evolution · 2016Article
- Genotyping of geographically diverse Druze trios reveals substructure and a recent bottleneck.European journal of human genetics : EJHG · 2015Article
- Estimation of epistatic variance components and heritability in founder populations and crosses.Genetics · 2014Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Widespread sharing of long, identical-by-descent (IBD) genetic segments is a hallmark of populations that have experienced recent genetic drift. Detection of these IBD segments has recently become feasible, enabling a wide range of applications from phasing and imputation to demographic inference. Here, we study the distribution of IBD sharing in the Wright-Fisher model. Specifically, using coalescent theory, we calculate the variance of the total sharing between random pairs of individuals. We then investigate the cohort-averaged sharing: the average total sharing between one individual and the rest of the cohort. We find that for large cohorts, the cohort-averaged sharing is distributed approximately normally. Surprisingly, the variance of this distribution does not vanish even for large cohorts, implying the existence of "hypersharing" individuals. The presence of such individuals has consequences for the design of sequencing studies, since, if they are selected for whole-genome sequencing, a larger fraction of the cohort can be subsequently imputed. We calculate the expected gain in power of imputation by IBD and subsequently in power to detect an association, when individuals are either randomly selected or specifically chosen to be the hypersharing individuals. Using our framework, we also compute the variance of an estimator of the population size that is based on the mean IBD sharing and the variance in the sharing between inbred siblings. Finally, we study IBD sharing in an admixture pulse model and show that in the Ashkenazi Jewish population the admixture fraction is correlated with the cohort-averaged sharing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.