ArticleThe Journal of experimental medicine2013
Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity.
Article in The Journal of experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- ImmunoMatch learns and predicts cognate pairing of heavy and light immunoglobulin chains.Nature methods · 2026Article
- Peripheral apoptosis and limited clonal deletion during physiologic murine B lymphocyte development.Nature communications · 2024Article
- Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity.Frontiers in immunology · 2024Article
- Role of inhibitory signaling in peripheral B cell tolerance.Immunological reviews · 2022Review
- B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells.Immunological reviews · 2022Review
- Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus.Nature communications · 2018Article
- Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.Frontiers in immunology · 2018Review
- Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production.The Journal of experimental medicine · 2016Article
- Receptor editing and genetic variability in human autoreactive B cells.The Journal of experimental medicine · 2016Article
- In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire.Nature medicine · 2015Article
- CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity?Current opinion in immunology · 2014Review
- Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM.European journal of immunology · 2014Article
- Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells.The Journal of experimental medicine · 2013Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
The important subtleties of B cell tolerance are best understood in a diverse immunoglobulin (Ig) repertoire context encoding a full spectrum of autoreactivity. To achieve this, we used mice expressing Igκ transgenes that confer varying degrees of autoreactivity within a diverse heavy chain (HC) repertoire. These transgenes, coupled with a biomarker to identify receptor-edited cells and combined with expression cloning of B cell receptors, allowed us to analyze tolerance throughout B cell development. We found that both the nature of the autoantigen and the Ig HC versus light chain (LC) contribution to autoreactivity dictate the developmental stage and mechanism of tolerance. Furthermore, although selection begins in the bone marrow, over one third of primary tolerance occurs in the periphery at the late transitional developmental stage. Notably, we demonstrate that the LC has profound effects on tolerance and can lead to exacerbated autoantibody production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.