ArticleHypertension (Dallas, Tex. : 1979)2013
Parental smoking in pregnancy and the risks of adult-onset hypertension.
Article in Hypertension (Dallas, Tex. : 1979), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study.Hypertension (Dallas, Tex. : 1979) · 2023Pooled it
- Prenatal smoking exposure and cardio-metabolic risk factors in adulthood: a general population study and a meta-analysis.International journal of obesity (2005) · 2019Pooled it
- Pre-pregnancy parental BMI and offspring blood pressure in infancy.European journal of preventive cardiology · 2019Trial
- Association of maternal smoking during pregnancy with youth depression and subsequent adult chronic diseases in offspring.Translational psychiatry · 2026Article
- Sexual Dimorphism in Cardiometabolic Diseases: From Development to Senescence and Therapeutic Approaches.Cells · 2025Review
- Maternal Smoking Intensity During Pregnancy and Early Adolescent Cardiovascular Health.Journal of the American Heart Association · 2025Article
- Involuntary tobacco smoke exposures from conception to 18 years increase midlife cardiometabolic disease risk: a 40-year longitudinal study.Journal of developmental origins of health and disease · 2023Article
- The impact of early adversity on the cerebral cortex - a Mendelian randomization study.Frontiers in neuroscience · 2023Article
- Interactions among maternal smoking, breastfeeding, and offspring genetic factors on the risk of adult-onset hypertension.BMC medicine · 2022Article
- Fetal Exposure to Maternal Smoking and Neonatal Metabolite Profiles.Metabolites · 2022Article
- Fetal and Childhood Exposure to Parental Tobacco Smoking and Arterial Health at Age 10 Years.American journal of hypertension · 2022Article
- Developmental origins of adult diseases.Medical review (2021) · 2022Review
- Foetal tobacco and cannabis exposure, body fat and cardio-metabolic health in childhood.Pediatric obesity · 2022Article
- Short stature is associated with low flow-mediated vasodilation in Japanese men.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Perinatal exposure to maternal smoking and adulthood smoking behaviors in predicting cardiovascular diseases: A prospective cohort study.Atherosclerosis · 2021Article
- Association between height and hypertension among US adults: analyses of National Health and Nutrition Examination Survey 2007-18.Clinical hypertension · 2021Article
- E-Cigarettes and Cardiopulmonary Health.Function (Oxford, England) · 2021Review
- Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?Frontiers in cardiovascular medicine · 2021Review
- Risk of hypertension into adulthood in persons born prematurely: a national cohort study.European heart journal · 2020Article
- Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review.PloS one · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Fetal exposure to parental smoking may lead to developmental adaptations and promote various diseases in later life. This study evaluated the associations of parental smoking during pregnancy with the risk of hypertension in the daughter in adulthood, and assessed whether these associations are explained by birth weight or body weight throughout life. We used data on 33086 participants of the Nurses' Health Study II and the Nurses' Mothers' Cohort. Cox proportional hazards models were used to examine the associations of maternal and paternal smoking during pregnancy with the nurse daughter, with self-reported physician-diagnosed hypertension from 1989 until 2007. Overall, 8575 (25.9%) mothers and 18874 (57.0%) fathers smoked during pregnancy. During follow-up, 7825 incident cases of adult-onset hypertension were reported. Both maternal and paternal smoking of ≥ 15 cigarettes/d during pregnancy were associated with increased risks of hypertension (rate ratio, 1.19; 95% CI, 1.09-1.29; and rate ratio, 1.18; 95% CI, 1.12-1.25, respectively) in the age-adjusted models. Further adjustment for birth weight did not affect the effect estimates appreciably, whereas additional adjustment for body shape and weight until age 18, or current body mass index, attenuated the associations with both maternal and paternal smoking (rate ratio, 1.07; 95% CI, 0.98-1.16; and rate ratio, 1.06; 95% CI, 1.01-1.12, respectively). The associations of parental smoking during pregnancy with the risk of hypertension in the offspring were largely explained by body weight throughout life, suggesting that these associations may not reflect direct intrauterine mechanisms.
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