Evidence map›Paper›PMID 23266440›Full record

Trial reportContemporary clinical trials2013

Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial.

Cheryl L Rock, Tim E Byers, Graham A Colditz, Wendy Demark-Wahnefried, Patricia A Ganz, Kathleen Y Wolin, Anthony Elias, Helen Krontiras, Jingxia Liu, Michael Naughton and 5 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Contemporary clinical trials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06164119 (A Randomised Effectiveness-implementation Trial for Evaluating Dietary and Manual Treatment With Osteopathic Techniques on Quality of Life and on Modulation of the Inflammatory State of Patients Diagnosed With Breast Cancer Undergoing Antiestrogenic Hormonal Treatment.), which is not on this map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06164119 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomised Effectiveness-implementation Trial for Evaluating Dietary and Manual Treatment With Osteopathic Techniques on Quality of Life and on Modulation of the Inflammatory State of Patients Diagnosed With Breast Cancer Undergoing Antiestrogenic Hormonal Treatment.

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2023 to 2025Enrolled600ConditionsBreast CancerArmsmanual treatment with osteopathic techniques and nutritional treatment, manual treatment with osteopathic techniques, nutritional treatment
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Weight Loss Randomized Intervention Trials in Female Cancer Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016
    Pooled it
  7. Effects of a 12-week exercise-based intervention on weight management in overweight or obese breast cancer survivors: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  8. Trial
  9. Changes in Body Mass Index and Physical Activity Predict Changes in Vitality During a Weight Loss Trial in Breast Cancer Survivors.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018
    Trial
  10. Trial
  11. Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
    Trial
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Cheryl L RockUniversity of California, La Jolla, CA 92093, USA. clrock@ucsd.edu
Tim E Byers
Graham A Colditz
Wendy Demark-Wahnefried
Patricia A Ganz
Kathleen Y Wolin
Anthony Elias
Helen Krontiras
Jingxia Liu
Michael Naughton
Bilgé Pakiz
Barbara A Parker
Rebecca L Sedjo
Holly Wyatt
Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Group
University of Colorado Denver · USWashington University in St. Louis · USUniversity of California, San Diego · USUniversity of Alabama at Birmingham · USUCLA Jonsson Comprehensive Cancer Center

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Reducing Breast Cancer Recurrence with Weight Loss: A Vanguard TrialR01CA148791 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROCK, CHERYL L · 2010 to 2013
$4.9M
PROMOTING HEALTH IN PROSTATE &BREAST CANCERR01CA081191 · NCI · DUKE UNIVERSITY · PI DEMARK-WAHNEFRIED, WENDY · 2001 to 2005
$2.3M
RENEW Research-out to ENhancE Wellness Older SurvivorsR01CA106919 · NCI · DUKE UNIVERSITY · PI DEMARK-WAHNEFRIED, WENDY · 2004 to 2007
$2.1M
HEALTHY WEIGHT MANAGEMENT FOR BREAST CANCER SURVIVORSR21CA090413 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI ROCK, CHERYL L · 2002 to 2003
$243k
Hormones During Weight Loss in Breast Cancer SurvivorsR03CA101489 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI ROCK, CHERYL L · 2003 to 2004
$152k
NCATS NIH HHS UL1 TR000448NCI NIH HHS CA101489NCI NIH HHS CA106919NCI NIH HHS CA148791NCI NIH HHS CA23100NCI NIH HHS CA81191NCI NIH HHS CA90413NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA081191NCI NIH HHS R01 CA106919NCI NIH HHS R01 CA148791NCI NIH HHS R03 CA101489NCI NIH HHS R21 CA090413NCRR NIH HHS UL1 RR024992NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Breast cancer is the most common invasive cancer among women in developed countries. Obesity is a major risk factor for breast cancer recurrence and mortality in both pre- and postmenopausal women. Co-morbid medical conditions are common among breast cancer survivors. The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) study is a 4-year randomized clinical trial of 693 overweight/obese women aged ≥21years diagnosed with any early stage breast cancer (stages I[≥1cm]-III) within the previous five years, designed to demonstrate the feasibility of achieving sustained weight loss and to examine the impact of weight loss on quality of life and co-morbidities, and to enable future exploration of biochemical mechanisms linking obesity to lower likelihood of disease-free survival. This trial is strategically designed as a vanguard for a fully-powered trial of women who will be evaluated for breast cancer recurrence and disease-free survival. Participants were recruited between 2010 and 2012 at four sites, had completed initial therapies, and had a body mass index between 25 and 45kg/m(2). The intervention featured a group-based cognitive-behavioral weight loss program with telephone counseling and tailored newsletters to support initial weight loss and subsequent maintenance, with the goal of 7% weight loss at two years. This study has high potential to have a major impact on clinical management and outcomes after a breast cancer diagnosis. This trial initiates the effort to establish weight loss support for overweight or obese breast cancer survivors as a new standard of clinical care.

Indexed as

AgedBody Mass IndexBreast NeoplasmsCognitive Behavioral TherapyComorbidityDiet, ReducingDisease-Free SurvivalExercise TherapyFemaleHumansLongitudinal StudiesMiddle AgedNeoplasm Recurrence, LocalObesityOverweightPsychotherapy, Group

Identifiers

PMID23266440
PMCPMC3593786
OpenAlexW2171594571

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.