ReviewCurrent opinion in chemical biology2013
Siderocalins: Siderophore binding proteins evolved for primary pathogen host defense.
Review in Current opinion in chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025Review
- Review
- Review
- In defence of ferroptosis.Signal transduction and targeted therapy · 2025Review
- Brucellosis: Bacteriology, pathogenesis, epidemiology and role of the metallophores in virulence: a review.Frontiers in cellular and infection microbiology · 2025Review
- Article
- Microbial, proteomic, and metabolomic profiling of the estrous cycle in wild house mice.Microbiology spectrum · 2024Article
- Iron Status and Supplementation during Tuberculosis.Microorganisms · 2023Review
- The elements of life: A biocentric tour of the periodic table.Advances in microbial physiology · 2023Article
- Stealthy microbes: HowFrontiers in cellular and infection microbiology · 2022Review
- Extracellular haem utilization by the opportunistic pathogen Pseudomonas aeruginosa and its role in virulence and pathogenesis.Advances in microbial physiology · 2021Article
- On the utility of fluorescence-detection analytical ultracentrifugation in probing biomolecular interactions in complex solutions: a case study in milk.European biophysics journal : EBJ · 2020Article
- Article
- Iron Acquisition by Bacterial Pathogens: Beyond Tris-Catecholate Complexes.Chembiochem : a European journal of chemical biology · 2020Review
- Scavenging Bacterial Siderophores with Engineered Lipocalin Proteins as an Alternative Antimicrobial Strategy.Chembiochem : a European journal of chemical biology · 2020Review
- The Role of Iron and Siderophores in Infection, and the Development of Siderophore Antibiotics.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- The anti-bacterial iron-restriction defence mechanisms of egg white; the potential role of three lipocalin-like proteins in resistance against Salmonella.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019Article
- Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury.JCI insight · 2018Article
- Iron and infection.International journal of hematology · 2018Review
- Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors.Inflammatory bowel diseases · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Bacterial pathogens use siderophores to obtain iron from the host in order to survive and grow. The host defends against siderophore-mediated iron acquisition by producing siderocalins. Siderocalins are a siderophore binding subset of the lipocalin family of proteins. The design of the siderophore binding pocket gives siderocalins the ability to bind a wide variety of siderophores and protect the host against several pathogens. Siderocalins have been identified in humans, chickens, and quail, among other animals. The differences in the respective siderocalins suggest that each was developed in response to the most serious pathogens encountered by that animal. Additionally, siderocalins have been observed in many roles unrelated to pathogen defense including differentiation, embryogenesis, inflammation, and cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.