ReviewThe Journal of allergy and clinical immunology2013
Can we produce true tolerance in patients with food allergy?
Review in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 82 citations in OpenAlex.
- Tolerance Induction in Cow's Milk Allergic Children by Heated Cow's Milk Protein: The iAGE Follow-Up Study.Nutrients · 2023Trial
- Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens.Immunological reviews · 2026Review
- Long-term efficacy and safety of cow's milk anaphylaxis specific immunotherapy: Allergen unresponsiveness via the Tolerance Induction Program.The journal of allergy and clinical immunology. Global · 2024Article
- The extrinsic factors important to the homeostasis of allergen-specific memory CD4 T cells.Frontiers in immunology · 2022Review
- Masked Delivery of Allergen in Nanoparticles Safely Attenuates Anaphylactic Response in Murine Models of Peanut Allergy.Frontiers in allergy · 2022Article
- Comparative Analysis of the Microbiome across the Gut-Skin Axis in Atopic Dermatitis.International journal of molecular sciences · 2021Review
- Combined Effects ofAllergy, asthma & immunology research · 2020Article
- New Perspectives in Food Allergy.International journal of molecular sciences · 2020Review
- Evolution of Immune Responses in Food Immunotherapy.Immunology and allergy clinics of North America · 2020Review
- Review
- Immunotherapy of Food Allergy: a Comprehensive Review.Clinical reviews in allergy & immunology · 2019Review
- Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Oral Tolerance Development and Maintenance.Immunology and allergy clinics of North America · 2018Review
- Forkhead box protein 3 demethylation is associated with tolerance induction in peanut-induced intestinal allergy.The Journal of allergy and clinical immunology · 2018Article
- The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.Clinical and translational allergy · 2017Article
- Deciphering the black box of food allergy mechanisms.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Review
- Epicutaneous immunotherapy induces gastrointestinal LAPThe Journal of allergy and clinical immunology · 2017Article
- Update on Early Nutrition and Food Allergy in Children.Yonsei medical journal · 2016Review
- Probiotics enhance the effect of allergy immunotherapy on regulating antigen specific B cell activity in asthma patients.American journal of translational research · 2016Article
- Engineering the Microbiome: a Novel Approach to Immunotherapy for Allergic and Immune Diseases.Current allergy and asthma reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Immune tolerance is defined as nonresponsiveness of the adaptive immune system to antigens. Immune mechanisms preventing inappropriate immune reactivity to innocuous antigens include deletion of reactive lymphocytes and generation of regulatory T (Treg) cells. The normal response to food antigens is the generation of antigen-specific Treg cells. In patients with food allergy, the dominant immune response is a T(H)2-skewed T-cell response and the generation of food-specific IgE antibodies from B cells. It is not known whether a failure of the Treg cell response is behind this inappropriate immune response, but interventions that boost the Treg cell response, such as mucosal immunotherapy, might lead to a restoration of immune tolerance to foods. Tolerance has been notoriously difficult to restore in animal disease models, but limited data from human trials suggest that tolerance (sustained nonresponsiveness) can be re-established in a subset of patients. Furthermore, studies on the natural history of food allergy indicate that spontaneous development of tolerance to foods over time is not uncommon. The current challenge is to understand the mechanisms responsible for restoration of natural or induced tolerance so that interventions can be developed to more successfully induce tolerance in the majority of patients with food allergy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.