ArticleNuclear medicine and biology2013
Evaluation of [18F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice.
Article in Nuclear medicine and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Disruption of normal brain distribution of [NeuroImage · 2025Article
- Abnormal [Synapse (New York, N.Y.) · 2023Article
- Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed byThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- [Molecules (Basel, Switzerland) · 2021Article
- Radiosynthesis and characterization of [European journal of nuclear medicine and molecular imaging · 2021Article
- An Optimized MicroPET Imaging Method for the Distribution and Synergies of Natural Products.Frontiers in pharmacology · 2018Article
- Human brain imaging of nicotinic acetylcholine α4β2* receptors using [The Journal of comparative neurology · 2018Article
- Human biodistribution and dosimetry of [Nuclear medicine and biology · 2017Article
- [Synapse (New York, N.Y.) · 2017Article
- Radiation dosimetry of the αEJNMMI physics · 2016Article
- Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [(18)F]Fluspidine-A New Tracer in Clinical Translation for Imaging of σ₁ Receptors.Molecules (Basel, Switzerland) · 2016Article
- Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors.Current topics in medicinal chemistry · 2016Review
- Development of novel approach to diagnostic imaging of lung cancer withJournal of cancer research & therapy · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
introduction[(18)F]Nifene is a novel radiotracer specific to the nicotinic acetylcholine α4β2 receptor class. In preparation for using this tracer in humans we have performed whole-body PET studies in mice to evaluate the in vivo biodistribution and dosimetry of [(18)F]Nifene.
methodsSeven BALB/c mice (3 males, 4 females) received IV tail injections of [(18)F]Nifene and were scanned for 2 h in an Inveon dedicated PET scanner. Each animal also received a high resolution CT scan using an Inveon CT. The CT images were used to draw volume of interest (VOI) on the following organs: brain, large intestine, small intestine, stomach, heart, kidneys, liver, lungs, pancreas, bone, spleen, testes, thymus, uterus and urinary bladder. All organ time activity curves had the decay correction reversed and were normalized to the injected activity. The area under the normalized curves was then used to compute the residence times in each organ. The absorbed doses in mouse organs were computed using the RAdiation Dose Assessment Resource (RADAR) animal models for dose assessment. The residence times in mouse organs were converted to human values using scale factors based on differences between organ and body weights. OLINDA 1.1 software was used to compute the absorbed human doses in multiple organs for both female and male phantoms.
resultsThe highest mouse residence times were found in urinary bladder, liver, bone, small intestine and kidneys. The largest doses in mice were found in urinary bladder and kidneys for both females and males. The elimination of radiotracer was primarily via kidney and urinary bladder with the urinary bladder being the limiting organ. The projected human effective doses were 1.51E-02 mSv/MBq for the adult male phantom and 1.65E-02 mSv/MBq for the adult female model phantom.
conclusionThis study indicates that the whole-body mouse imaging can be used as a preclinical tool for initial estimation of the absorbed doses of [(18)F]Nifene in humans.
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