ArticleNeural networks : the official journal of the International Neural Network Society2013
Cross-correlations between pairs of neurons in cerebellar cortex in vivo.
Article in Neural networks : the official journal of the International Neural Network Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 23 citations in OpenAlex.
- Widely Different Correlation Patterns Between Pairs of Adjacent Thalamic NeuronsFrontiers in neural circuits · 2021Article
- Response Dynamics in an Olivocerebellar Spiking Neural Network With Non-linear Neuron Properties.Frontiers in computational neuroscience · 2019Article
- Absence of Repetitive Correlation Patterns Between Pairs of Adjacent Neocortical NeuronsFrontiers in neural circuits · 2019Article
- Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior.Scientific reports · 2017Article
- Artificial spatiotemporal touch inputs reveal complementary decoding in neocortical neurons.Scientific reports · 2017Article
- Long Pauses in Cerebellar Interneurons in Anesthetized Animals.Cerebellum (London, England) · 2017Article
- Cerebellar physiology: links between microcircuitry properties and sensorimotor functions.The Journal of physiology · 2017Review
- Time-invariant feed-forward inhibition of Purkinje cells in the cerebellar cortex in vivo.The Journal of physiology · 2016Article
- Mechanisms for motor timing in the cerebellar cortex.Current opinion in behavioral sciences · 2016Article
- Cerebellar Synaptic Plasticity and the Credit Assignment Problem.Cerebellum (London, England) · 2016Review
- Functional dissection of synaptic circuits: in vivo patch-clamp recording in neuroscience.Frontiers in neural circuits · 2015Review
- Memory trace and timing mechanism localized to cerebellar Purkinje cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Simulating spinal border cells and cerebellar granule cells under locomotion--a case study of spinocerebellar information processing.PloS one · 2014Article
- Properties of bilateral spinocerebellar activation of cerebellar cortical neurons.Frontiers in neural circuits · 2014Article
- Parallel fiber and climbing fiber responses in rat cerebellar cortical neurons in vivo.Frontiers in systems neuroscience · 2013Article
- Cerebellar cortical neuron responses evoked from the spinal border cell tract.Frontiers in neural circuits · 2013Article
- Processing of multi-dimensional sensorimotor information in the spinal and cerebellar neuronal circuitry: a new hypothesis.PLoS computational biology · 2013Article
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3 authors at 1 institution in 1 country.
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Abstract
In the present paper we apply a new neurophysiological technique to make single-electrode, dual loose-patch recordings from pairs of neuronal elements in the cerebellar cortex in vivo. The analyzed cell pairs consisted of an inhibitory molecular layer interneuron and a Purkinje cell (PC) or a Golgi cell and a granule cell, respectively. To detect the magnitude of the unitary inhibitory synaptic inputs we used histograms of the spike activity of the target cell, triggered by the spikes of the inhibitory cell. Using this analysis, we found that single interneurons had no detectable effect on PC firing, which could be explained by an expected very low synaptic weight of individual interneuron-PC connections. However, interneurons did have a weak delaying effect on the overall series of interspike intervals of PCs. Due to the very high number of inhibitory synapses on each PC, a concerted activation of the interneurons could still achieve potent PC inhibition as previously shown. In contrast, in the histograms of the Golgi cell-granule cell pairs, we found a weak inhibitory effect on the granule cell but only at the time period defined as the temporal domain of the slow IPSP previously described for this connection. Surprisingly, the average granule cell firing frequency sampled at one second was strongly modulated with a negative correlation to the overall firing level of the Golgi cell when the latter was modified through current injection via the patch pipette. These findings are compatible with that tonic inhibition is the dominant form of Golgi cell-granule cell inhibition in the adult cerebellum in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.