ArticleVeterinary microbiology2013
Modulation of chemokine and chemokine receptor expression following infection of porcine macrophages with African swine fever virus.
Article in Veterinary microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Intranasal inoculation with African swine fever virus genotype II reveals dose-dependent infectivity, pathogenesis and diagnostic challenges in pigs.The veterinary quarterly · 2025Article
- Anti-pA137R antibodies exacerbate the pathogenicity of African swine fever virus in pigs.Journal of virology · 2025Article
- The transcriptomic insight into the differential susceptibility of African Swine Fever in inbred pigs.Scientific reports · 2024Article
- Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating CaJournal of virology · 2023Article
- Molecular Signatures in Swine Innate and Adaptive Immune Responses to African Swine Fever Virus Antigens p30/p54/CD2v Expressed Using a Highly Efficient Semliki Forest Virus Replicon System.International journal of molecular sciences · 2023Article
- Transcriptome Profiling in Swine Macrophages Infected with African Swine Fever Virus (ASFV) Uncovers the Complex and Close Relationship with Host.Pathogens (Basel, Switzerland) · 2022Article
- Host Responses to Live-Attenuated ASFV (HLJ/18-7GD).Viruses · 2022Article
- Regulation of antiviral immune response by African swine fever virus (ASFV).Virologica Sinica · 2022Review
- Adaptive Cellular Immunity against African Swine Fever Virus Infections.Pathogens (Basel, Switzerland) · 2022Review
- Analyses of the Impact of Immunosuppressive Cytokines on Porcine Macrophage Responses and Susceptibility to Infection to African Swine Fever Viruses.Pathogens (Basel, Switzerland) · 2022Article
- Mechanism of interaction between virus and host is inferred from the changes of gene expression in macrophages infected with African swine fever virus CN/GS/2018 strain.Virology journal · 2021Article
- African Swine Fever Virus Induces STAT1 and STAT2 Degradation to Counteract IFN-I Signaling.Frontiers in microbiology · 2021Article
- Transcriptome view of a killer: African swine fever virus.Biochemical Society transactions · 2020Review
- Modulation of Type I Interferon System by African Swine Fever Virus.Pathogens (Basel, Switzerland) · 2020Article
- Comparison of Macrophage Responses to African Swine Fever Viruses Reveals that the NH/P68 Strain is Associated with Enhanced Sensitivity to Type I IFN and Cytokine Responses from Classically Activated Macrophages.Pathogens (Basel, Switzerland) · 2020Article
- Cytokine Storm in Domestic Pigs Induced by Infection of Virulent African Swine Fever Virus.Frontiers in veterinary science · 2020Article
- Gene expression analysis of whole blood RNA from pigs infected with low and high pathogenic African swine fever viruses.Scientific reports · 2017Article
- African swine fever virus infection in Classical swine fever subclinically infected wild boars.BMC veterinary research · 2017Article
- Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge.Journal of virology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
African swine fever virus (ASFV) is the only member of the Asfarviridae, a large DNA virus family which replicates predominantly in the cytoplasm. Most isolates cause a fatal haemorrhagic disease in domestic pigs, although some low virulence isolates cause little or no mortality. The modulation of chemokine responses following infection of porcine macrophages with low and high virulence isolates was studied to indicate how this may be involved in the induction of pathogenesis and of effective immune responses. Infection with both low and high virulence isolates resulted in down-regulation of mRNA levels for chemokines CCL2, CCL3L, CXCL2 and chemokine receptors CCR1, CCR5, CXCR3, CXCR4 and up-regulation in expression of mRNAs for CCL4, CXCL10 and chemokine receptor CCR7. Levels of CCL4, CXCL8, CXCL10 mRNAs were higher in macrophages infected with low virulence isolate OURT88/3 compared to high virulence isolate Benin 97/1. Levels of CXCL8 and CCL2 protein were significantly reduced in supernatants from macrophages infected with Benin 97/1 isolate compared to OURT88/3 and mock-infected macrophages. There was also a decreased chemotactic response of donor cells exposed to supernatants from Benin 97/1 infected macrophages compared to those from OURT88/3 and mock-infected macrophages. The data show that infection of macrophages with the low virulence strain OURT88/3 induces higher expression of key inflammatory chemokines compared to infection with high virulence strain Benin 97/1. This may be important for the induction of effective protective immunity that has been observed in pigs immunised with the OURT88/3 isolate.
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Registered trials
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