ArticleFrontiers in microbiology2012
Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity?
Article in Frontiers in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Pilot Study Comparing the In Vitro Response of Circulating Monocytes toJournal of fungi (Basel, Switzerland) · 2025Article
- Interplay of Cytokines and Chemokines in Aspergillosis.Journal of fungi (Basel, Switzerland) · 2024Review
- Accelerating the understanding ofCurrent research in microbial sciences · 2024Review
- "Under Pressure" - How fungi evade, exploit, and modulate cells of the innate immune system.Seminars in immunology · 2023Review
- Serum Cytokine Profile in Patients with Candidemia versus Bacteremia.Pathogens (Basel, Switzerland) · 2021Article
- Diagnostic efficacy of serum cytokines and chemokines in fungal bloodstream infection in febrile patients.Journal of clinical laboratory analysis · 2020Article
- Response of Human Neutrophil Granulocytes to the Hyphae of the Emerging Fungal PathogenPathogens (Basel, Switzerland) · 2020Article
- Aspergillus fumigatus enhances human NK cell activity by regulating M1 macrophage polarization.Molecular medicine reports · 2019Article
- miRNA-344b-1-3p modulates the autophagy of NR8383 cells duringExperimental and therapeutic medicine · 2019Article
- Pathogenic Fungal Infection in the Lung.Frontiers in immunology · 2019Review
- Fungal Pathogens in CF Airways: Leave or Treat?Mycopathologia · 2018Review
- IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.American journal of respiratory and critical care medicine · 2018Article
- First Insights in NK-DC Cross-Talk and the Importance of Soluble Factors During Infection WithFrontiers in cellular and infection microbiology · 2018Article
- Preparations for Invasion: Modulation of Host Lung Immunity During PulmonaryFrontiers in immunology · 2018Review
- Microbial volatile communication in human organotypic lung models.Nature communications · 2017Article
- The Multifaceted Role of T-Helper Responses in Host Defense against Aspergillus fumigatus.Journal of fungi (Basel, Switzerland) · 2017Review
- Control of Phagocytosis by Microbial Pathogens.Frontiers in immunology · 2017Review
- Interaction of THP-1 Monocytes with Conidia and Hyphae of DifferentFrontiers in immunology · 2017Article
- Anti-Immune Strategies of Pathogenic Fungi.Frontiers in cellular and infection microbiology · 2016Review
- Current Concepts and Controversies in Innate Immunity of Cystic Fibrosis Lung Disease.Journal of innate immunity · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive aspergillosis is a significant threat to health and is a major cause of mortality in immunocompromised individuals. Understanding the interaction between the fungus and the immune system is important in determining how the immunocompetent host remains disease free. Several studies examining the direct interaction between Aspergillus fumigatus and purified innate immune cells have been conducted to measure the responses of both the host cells and the pathogen. It has been revealed that innate immune cells have different modes of action ranging from effective fungal killing by neutrophils to the less aggressive response of dendritic cells. Natural killer cells do not phagocytose the fungus unlike the other innate immune cells mentioned but appear to mediate their antifungal effect through the release of gamma interferon. Transcriptional analysis of A. fumigatus interacting with these cells has indicated that it can adapt to the harsh microenvironment of the phagosome and produces toxins, ribotoxin and gliotoxin, that can induce cell death in the majority of innate immune cells. These data point toward potential novel antifungal treatments including the use of innate immune cells as antifungal vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.