Evidence map›Paper›PMID 23264695›Full record

ArticleCoordination chemistry reviews2013

Iron metabolism in aerobes: managing ferric iron hydrolysis and ferrous iron autoxidation.

Daniel J Kosman

Open access · greenAbstract read
In one paragraph

Article in Coordination chemistry reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Iron Homeostasis in Insects.Annual review of entomology · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. The Hunger Games:Frontiers in immunology · 2021
    Article
  10. Article
  11. A holistic view of mammalian (vertebrate) cellular iron uptake.Metallomics : integrated biometal science · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Is brain iron trafficking part of the physiology of the amyloid precursor protein?Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019
    Article
  17. The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review.Tropical medicine and infectious disease · 2019
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Daniel J KosmanUniversity at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
University at Buffalo, State University of New York · US

Funding

Managing ionic iron: ferri-reduction, ferro-oxidation and iron permeationR01DK053820 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KOSMAN, DANIEL J. · 1999 to 2016
$4.0M
Managing ionic iron: ferri-reduction, ferro-oxidation and iron permeationR56DK053820 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KOSMAN, DANIEL J. · 2013 to 2013
$155k
NIDDK NIH HHS R01 DK053820NIDDK NIH HHS R56 DK053820
6 · The paper itself

Abstract

Aerobes and anaerobes alike express a plethora of essential iron enzymes; in the resting state, the iron atom(s) in these proteins are in the ferrous state. For aerobes, ferric iron is the predominant environmental valence form which, given ferric iron's aqueous chemistry, occurs as 'rust', insoluble, bio-inert polymeric ferric oxide that results from the hydrolysis of [Fe(H(2)O)(6)](3+). Mobilizing this iron requires bio-ferrireduction which in turn requires managing the rapid autoxidation of the resulting Fe(II) which occurs at pH > 6. This review examines the aqueous redox chemistry of iron and the mechanisms evolved in aerobes to suppress the 'rusting out' of Fe(III) and the ROS-generating autoxidation of Fe(II) so as to make this metal ion available as the most ubiquitous prosthetic group in metallobiology.

Identifiers

PMID23264695
PMCPMC3524981
OpenAlexW2062213135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.