ArticleAmerican journal of Alzheimer's disease and other dementias2013
Restless legs syndrome in a group of patients with Alzheimer's disease.
Article in American journal of Alzheimer's disease and other dementias, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.The Lancet. Neurology · 2017Pooled it
- Recommendations of the Sleep Study Group of the Italian Dementia Research Association (SINDem) on clinical assessment and management of sleep disorders in individuals with mild cognitive impairment and dementia: a clinical review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Pooled it
- Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review.Journal of clinical medicine · 2026Review
- The rhythm of decline: Circadian disruption in neurodegeneration.Journal of food and drug analysis · 2025Review
- Restless legs syndrome and ferritin levels in older adults with dementia: a cross-sectional study.Dementia & neuropsychologia · 2025Article
- Circadian disruption and sleep disorders in neurodegeneration.Translational neurodegeneration · 2023Review
- Sleep Disorders Associated With Alzheimer's Disease: A Perspective.Frontiers in neuroscience · 2018Review
- Sleep Disturbance, Cognitive Decline, and Dementia: A Review.Seminars in neurology · 2017Review
- Iron and restless legs syndrome: treatment, genetics and pathophysiology.Sleep medicine · 2017Article
- Clinical management of sleep disturbances in Alzheimer's disease: current and emerging strategies.Nature and science of sleep · 2016Review
- Auditory and Lower Limb Tactile Prepulse Inhibition in Primary Restless Legs Syndrome: Clues to Its Pathophysiology.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRestless legs syndrome (RLS) is a neurological disorder characterized by the urge to move the legs associated with peculiar unpleasant sensations during periods of rest and inactivity that are relieved by movement. A few studies analyzed RLS in neurodegenerative diseases such as Alzheimer's Disease (AD). The aim of our study was to assess the prevalence and the clinical characteristics of RLS in a cohort of AD patients.
methodsThree hundred and thirty-nine subjects with a diagnosis of AD were recruited. Cognitive, functional, and neuropsychiatric measures were collected at baseline and six-monthly for a 2-years follow-up
resultsFourteen subjects met the RLS criteria. RLS subjects were more frequently male (p:0,006) and younger than AD subject without RLS (p:0,029). MMSE, ADL and IADL were not significantly different. NPI total scores did not differ significantly, however, AD patients with RLS were found to be more apathetic (p:0,001) than AD subjects without RLS.
conclusionRLS prevalence in our AD cohort was estimated to be about 4%. RLS appeared to be associated with neuropsychiatric symptoms such as apathy. RLS and apathy might share a common pathophysiological basis represented by a dysfunction of the central dopaminergic system.
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