ArticleEukaryotic cell2013
Transcriptional changes in the transition from vegetative cells to asexual development in the model fungus Aspergillus nidulans.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans.Journal of microbiology (Seoul, Korea) · 2021Article
- Transcription Factors in the FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Naturally Occurring Phenols Modulate Vegetative Growth and Deoxynivalenol Biosynthesis inACS omega · 2020Article
- Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway.mBio · 2020Article
- Copper Homeostasis inFrontiers in microbiology · 2020Article
- Identification and Characterization ofCells · 2019Article
- The Early Asexual Development RegulatorFrontiers in microbiology · 2019Article
- Evolution of asexual and sexual reproduction in the aspergilli.Studies in mycology · 2018Article
- Article
- High-throughput format for the phenotyping of fungi on solid substrates.Scientific reports · 2017Article
- Copper Resistance inFrontiers in microbiology · 2017Article
- Discovery of McrA, a master regulator of Aspergillus secondary metabolism.Molecular microbiology · 2017Article
- Siderophore Biosynthesis but Not Reductive Iron Assimilation Is Essential for the Dimorphic Fungus Nomuraea rileyi Conidiation, Dimorphism Transition, Resistance to Oxidative Stress, Pigmented Microsclerotium Formation, and Virulence.Frontiers in microbiology · 2016Article
- The Adenylate-Forming Enzymes AfeA and TmpB Are Involved in Aspergillus nidulans Self-Communication during Asexual Development.Frontiers in microbiology · 2016Article
- A second component of the SltA-dependent cation tolerance pathway in Aspergillus nidulans.Fungal genetics and biology : FG & B · 2015Article
- Article
- The histone acetyltransferase GcnE (GCN5) plays a central role in the regulation of Aspergillus asexual development.Genetics · 2014Article
- Biotrophy-specific downregulation of siderophore biosynthesis in Colletotrichum graminicola is required for modulation of immune responses of maize.Molecular microbiology · 2014Article
- Control of reactive oxygen species (ROS) production through histidine kinases in Aspergillus nidulans under different growth conditions.FEBS open bio · 2014Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenesis encompasses programmed changes in gene expression that lead to the development of specialized cell types. In the model fungus Aspergillus nidulans, asexual development involves the formation of characteristic cell types, collectively known as the conidiophore. With the aim of determining the transcriptional changes that occur upon induction of asexual development, we have applied massive mRNA sequencing to compare the expression pattern of 19-h-old submerged vegetative cells (hyphae) with that of similar hyphae after exposure to the air for 5 h. We found that the expression of 2,222 (20.3%) of the predicted 10,943 A. nidulans transcripts was significantly modified after air exposure, 2,035 being downregulated and 187 upregulated. The activation during this transition of genes that belong specifically to the asexual developmental pathway was confirmed. Another remarkable quantitative change occurred in the expression of genes involved in carbon or nitrogen primary metabolism. Genes participating in polar growth or sexual development were transcriptionally repressed, as were those belonging to the HogA/SakA stress response mitogen-activated protein (MAP) kinase pathway. We also identified significant expression changes in several genes purportedly involved in redox balance, transmembrane transport, secondary metabolite production, or transcriptional regulation, mainly binuclear-zinc cluster transcription factors. Genes coding for these four activities were usually grouped in metabolic clusters, which may bring regulatory implications for the induction of asexual development. These results provide a blueprint for further stage-specific gene expression studies during conidiophore development.
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