ReviewMolecular human reproduction2013
ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies.
Review in Molecular human reproduction, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach.Nature communications · 2021Trial
- Epigenetic, environmental, and sex-specific programming of long-term health in Assisted Reproductive Technologies-conceived offspring†.Biology of reproduction · 2026Review
- Redox imbalance in infertility and assisted reproduction: biomarkers, mechanisms, multi-omics integration, and personalised therapeutic strategies.Frontiers in medicine · 2026Review
- Reproductive Health and Assisted Conception in Celiac Disease and Non-Celiac Gluten Sensitivity: A Narrative Review.Nutrients · 2025Review
- A Review: Biomechanical Aspects of the Fallopian Tube Relevant to its Function in Fertility.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- DNA methylation profile of liver of mice conceived byJournal of developmental origins of health and disease · 2022Article
- Ovulation induction is associated with altered growth but with preservation of normal metabolic function in murine offspring.F&S science · 2021Article
- Article
- The effects of assisted reproduction technologies on metabolic health and disease†.Biology of reproduction · 2021Review
- Conditions of embryo culture from days 5 to 7 of development alter the DNA methylome of the bovine fetus at day 86 of gestation.Journal of assisted reproduction and genetics · 2020Article
- Obstetric and perinatal outcomes of singleton pregnancies conceived via assisted reproductive technology complicated by gestational diabetes mellitus: a prospective cohort study.BMC pregnancy and childbirth · 2018Article
- Evaluation of prooxidant-antioxidant balance inClinical and experimental reproductive medicine · 2018Article
- Transitioning from Infertility-Based (ART 1.0) to Elective (ART 2.0) Use of Assisted Reproductive Technologies and the DOHaD Hypothesis: Do We Need to Change Consenting?Seminars in reproductive medicine · 2018Review
- Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events.Human reproduction update · 2018Review
- The superovulated environment, independent of embryo vitrification, results in low birthweight in a mouse model.Biology of reproduction · 2017Article
- Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse.Reproductive toxicology (Elmsford, N.Y.) · 2017Review
- DNA methylation in spermatogenesis and male infertility.Experimental and therapeutic medicine · 2016Article
- From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies.Healthcare (Basel, Switzerland) · 2016Article
- Infertility treatment and children's longitudinal growth between birth and 3 years of age.Human reproduction (Oxford, England) · 2016Article
- Probing the germline-dependence of epigenetic inheritance using artificial insemination in mice.Environmental epigenetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Since the birth of the first IVF-conceived child in 1978, the use of assisted reproductive technologies (ART) has grown dramatically, contributing to the successful birth of 5 million individuals worldwide. However, there are several reported associations of ART with pregnancy complications, such as low birthweight (LBW), preterm birth, birth defects, epigenetic disorders, cancer and poor metabolic health. Whether this is attributed to ART procedures or to the subset of the population seeking ART remains a controversy, but the most relevant question today concerns the potential long-term implications of assisted conception. Recent evidence has emerged suggesting that ART-conceived children have distinct metabolic profiles that may predispose to cardiovascular pathologies in adulthood. Because the eldest IVF individuals are still too young to exhibit components of chronic middle-aged syndromes, the use of animal models has become particularly useful in describing the effects of unusual or stressful preimplantation experiences on adult fitness. Elucidating the molecular mechanisms by which embryos integrate environmental signals into development and metabolic gene expression programs will be essential for optimizing ART procedures such as in vitro culture conditions, embryo selection and transfer. In the future, additional animal studies to identify mechanisms underlying unfavorable ART outcomes, as well as more epidemiological reviews to monitor the long-term health of ART children are required, given that ART procedures have become routine medical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.