ArticleArchives of disease in childhood2013
Drug use and upper gastrointestinal complications in children: a case-control study.
Article in Archives of disease in childhood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Efficacy and Safety of Paracetamol and NSAIDs for Fever and Pain Management in Children with Chronic Diseases: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Adverse reactions to acetaminophen and ibuprofen in pediatric patients: a narrative review.Italian journal of pediatrics · 2025Review
- Intravenously Administered Nonsteroidal Anti-Inflammatory Drugs in Clinical Practice: A Narrative Review.Pharmacy (Basel, Switzerland) · 2025Review
- Comparative Analyses of the Safety Profiles of Vitamin D Receptor Agonists: A Pharmacovigilance Study Based on the EudraVigilance Database.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.Paediatric drugs · 2022Review
- Factors Influencing HIV Status Disclosure to Partners Among Antiretroviral Therapy Clients in the Upper East Region, Ghana.AIDS and behavior · 2022Article
- Atypical Reye syndrome: three cases of a problem that pediatricians should consider and remember.Acta bio-medica : Atenei Parmensis · 2021Article
- Prescribing patterns, indications and adverse events of ibuprofen in children: results from a national survey among Italian pediatricians.Italian journal of pediatrics · 2021Article
- Serious infectious events and ibuprofen administration in pediatrics: a narrative review in the era of COVID-19 pandemic.Italian journal of pediatrics · 2021Review
- Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months.Paediatric drugs · 2017Review
- Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal.Drugs · 2017Review
- Antibiotic-Induced Liver Injury in Paediatric Outpatients: A Case-Control Study in Primary Care Databases.Drug safety · 2017Article
- A clinical and safety review of paracetamol and ibuprofen in children.Inflammopharmacology · 2017Review
- Henoch-Schönlein purpura and drug and vaccine use in childhood: a case-control study.Italian journal of pediatrics · 2016Article
- Italian survey on non-steroidal anti-inflammatory drugs and gastrointestinal bleeding in children.World journal of gastroenterology · 2016Observational
- Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.Microbial ecology in health and disease · 2015Article
- A practical approach to the treatment of low-risk childhood fever.Drugs in R&D · 2014Review
- Paracetamol: a focus for the general pediatrician.European journal of pediatrics · 2014Review
- [Economic effects of chronic pain in childhood and adolescence: self-assessment of health care costs for affected families before and after a multidisciplinary inpatient pain therapy].Schmerz (Berlin, Germany) · 2013Article
- Pharmacovigilance in Italy: An overview.Journal of pharmacology & pharmacotherapeutics · 2013Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population.
methodsThis study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug.
results486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p<0.001). UGICs were associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) (adjusted OR 2.9, 95% CI 2.1 to 4.0), oral steroids (adjusted OR 2.9, 95% CI 1.7 to 4.8) and antibiotics (adjusted OR 2.3, 95% CI 1.8 to 3.1). The duration of use of these drug categories was short (range 1-8 days). Paracetamol showed a lower risk (adjusted OR 2.0, 95% CI 1.5 to 2.6) compared to ibuprofen (adjusted OR 3.7, 95% CI 2.3 to 5.9), although with partially overlapping CIs.
conclusionsNSAIDs, oral steroids and antibiotics, even when administered for a short period, were associated with an increased risk of UGIC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.