Evidence map›Paper›PMID 23264150›Full record

ArticleJournal of the American Society for Mass Spectrometry2013

Comparison of MS/MS methods for characterization of DNA/cisplatin adducts.

Zhe Xu, Jared B Shaw, Jennifer S Brodbelt

Abstract readComparative Study
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Top-down mass spectrometry reveals multiple interactions of an acetylsalicylic acid bearing Zeise's salt derivative with peptides.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
  6. Specific Interactions of Antitumor Metallocenes with Deoxydinucleoside Monophosphates.Journal of the American Society for Mass Spectrometry · 2017
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zhe XuDepartment of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA.
Jared B Shaw
Jennifer S Brodbelt
The University of Texas at Austin · US

Funding

Design and Characterization of DNA Interactive AgentsR01GM065956 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI BRODBELT, JENNIFER S. · 2003 to 2011
$2.1M
NIGMS NIH HHS R01 GM065956NIGMS NIH HHS R01 GM65956
6 · The paper itself

Abstract

The development of activation/dissociation techniques such as ultraviolet photodissociation (UVPD), infrared multiphoton dissociation (IRMPD), and electron transfer dissociation (ETD) as alternatives to collision induced dissociation (CID) has extended the range of strategies for characterizing biologically relevant molecules. Here, we describe a comprehensive comparison of CID, IRMPD, UVPD, ETD, and hybrid processes termed ETcaD and ET-IRMPD (and analogous hybrid methods in the negative mode NETcaD and NET-IRMPD) for generating sequence-specific fragment ions and allowing adduction sites to be pinpointed for DNA/cisplatin adducts. Among the six MS/MS methods, the numerous products generated by the IRMPD and UVPD techniques resulted in the most specific and extensive backbone cleavages. We conclude that IRMPD and UVPD methods generally offer the best characteristics for pinpointing the cisplatin adduction sites in the fragment-rich spectra.

Indexed as

CisplatinDNA AdductsOligodeoxyribonucleotidesPhotochemical ProcessesTandem Mass SpectrometryCisplatincisplatin-DNA adductDNA AdductsOligodeoxyribonucleotides

Identifiers

PMID23264150
PMCPMC3570664
OpenAlexW2056384782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.