ArticleJournal of molecular histology2013
Involvement of transcription initiation factor IIB in the light-induced death of rat retinal ganglion cells in vivo.
Article in Journal of molecular histology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress.Genes & development · 2026Article
- Light-Induced Retinal Ganglion Cell Damage and the Relevant Mechanisms.Cellular and molecular neurobiology · 2020Review
- Down-regulation of Fra-2 alleviates light-induced retina damage by inhibiting the PARP-1/AIF pathway.International journal of clinical and experimental pathology · 2018Article
- Involvement of Fra-1 in Retinal Ganglion Cell Apoptosis in Rat Light-Induced Retina Damage Model.Cellular and molecular neurobiology · 2017Article
- Caspases in retinal ganglion cell death and axon regeneration.Cell death discovery · 2017Review
- The role of STAT transcription factors in apoptosis regulation of hypothalamic neurons in aging in HER-2/neu transgenic mice and wild-type FVB/N mice.Doklady. Biochemistry and biophysics · 2016Article
- Raf-1 Kinase Inhibitory Protein (RKIP) Promotes Retinal Ganglion Cell Survival and Axonal Regeneration Following Optic Nerve Crush.Journal of molecular neuroscience : MN · 2015Article
- Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats.Journal of molecular histology · 2014Article
- Spatiotemporal changes in NFATc4 expression of retinal ganglion cells after light-induced damage.Journal of molecular neuroscience : MN · 2014Article
- Upregulation of CREM-1 relates to retinal ganglion cells apoptosis after light-induced damage in vivo.Journal of molecular neuroscience : MN · 2014Article
- Expression of Werner syndrome gene in hypothalamic neurons in physiological aging.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2013Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription initiation factor IIB (TFIIB) is a general transcription initiation factor that plays a pivotal role in the response to transcriptional activator proteins. Previous reports have shown that TFIIB have been implicated in the pathogenesis of various experimental central nervous system diseases. However, its distribution and function in the retina remain unclear. In the present study, we investigated the spatiotemporal expression of TFIIB in a light-induced retinal damage model. Western blotting analysis showed TFIIB level significantly improved 3 days after injury, and then declined during the following days. The association of TFIIB and retinal ganglion cells (RGCs) was detected by immunofluorescence double staining. The injury-induced expression of TFIIB was physically co-existed with active caspase-3 and TUNEL (apoptotic markers). Spatiotemporal changes of TFIIB expression suggest that this protein may play a role in the degenerative process of RGCs by light-induced damage in the retina.
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