Evidence map›Paper›PMID 23264068›Full record

Trial reportJournal of clinical monitoring and computing2013

Outcome impact of goal directed fluid therapy during high risk abdominal surgery in low to moderate risk patients: a randomized controlled trial.

Davinder S Ramsingh, Chirag Sanghvi, Joseph Gamboa, Maxime Cannesson, Richard L Applegate

4 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of clinical monitoring and computing, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 40 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02312999 phase4completednot on this mapstarted 2015, after this paper: background citation

Phase IV, Multicentric, Prospective, Controlled, Randomized, Double Blind Study Comparing a Crystalloid to a Colloid Used in the Perioperatory Hemodynamic Optimisation With a 'Closed Loop' Automatic Filling System, on the Post-surgery Morbidity in Major Abdominal Surgery.

TypeinterventionalSponsorBrugmann University HospitalRan2015 to 2017Enrolled160ConditionsSurgeryArmsPlasmalyte, Volulyte
NCT02470221 completednot on this mapstarted 2016, after this paper: background citation

Effect of Goal-Directed Intraoperative Fluid Therapy on Outcomes Following Laparotomy of Gynecological Malignancies and Orthopedic Surgery

TypeobservationalSponsorHuang YuGuangRan2016 to 2018Enrolled600ConditionsPostoperative Complications, Fluid OverloadArmsApplying goal-directed fluid therapy by continuous hemodynamic monitoring system, Conventional fluid therapy
NCT03031600 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Pilot Validation of a Hemodilution Technique to Estimate Blood Volume in Vivo

TypeinterventionalSponsorUniformed Services University of the Health SciencesRan2017 to 2018Enrolled33ConditionsHypovolemia, HypervolemiaArmsRadiodilution via Daxor BVA-100, Hemodilution via hematocrit measurement
NCT03218540 nacompletednot on this mapstarted 2017, after this paper: background citation

Directed Fluid Therapy Based on Stroke Volume Variations Improves Fluid Management in Endovascular Aortic Repair for Aortic Aneurysm Patients: a Randomized Trial

TypeinterventionalSponsorKhon Kaen UniversityRan2017 to 2017Enrolled40ConditionsPostoperative ComplicationsArmsFluid management protocol
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  19. Optimal Perioperative Fluid Therapy Associates with Fewer Complications After Pancreaticoduodenectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Davinder S RamsinghDepartment of Anesthesiology, University of California at Irvine Medical Center, 333 The City Boulevard West, Suite 2150, Orange, CA 92868, USA. dramsing@uci.edu
Chirag Sanghvi
Joseph Gamboa
Maxime Cannesson
Richard L Applegate

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraoperative goal directed fluid therapy (GDT) guided by an arterial pressure-based cardiac output system has been reported to improve gastrointestinal (GI) recovery in high-risk patients. This study evaluates the impact of this approach on GI recovery in low to moderate risk patients undergoing major abdominal surgery. IRB approved randomized controlled trial in low to moderate risk adults scheduled for major surgery. Patients were randomized to standard (n = 20) or GDT (n = 18) groups, whose fluids were managed to maintain stroke volume variation (SVV) <12 %. The primary outcome measure was GI recovery. Additional measures included quality of recovery score. Continuous, non-normally distributed by Mann-Whitney test; ordinal and nominal by Chi square analysis. GDT patients had lower average intraoperative SVV. The GDT group had faster return of GI function (p = 0.004) and higher quality of recovery scores. In low to moderate risk patients undergoing major abdominal surgery, intraoperative GDT guided by SVV optimization was associated with faster restoration of GI recovery and higher quality of recovery scores. These results suggest that outcome benefits related to the use of an intraoperative goal directed fluid protocol guided by SVV are not limited to high-risk patients.

Indexed as

AbdomenAdultAgedAged, 80 and overFemaleFluid TherapyGastrointestinal TractHumansIntraoperative CareMaleMiddle AgedMonitoring, IntraoperativeProspective StudiesRisk FactorsSingle-Blind MethodStroke Volume

Identifiers

PMID23264068

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.