ArticleInfection and immunity2013
Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Epigenetic regulation of humoral immunity: molecular mechanisms, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Exploring the regulatory role of small RNAs in modulating host-pathogen interactions: implications for bacterial and viral infections.Molecular biology reports · 2025Review
- Gastrointestinal germinal center B cell depletion and reduction in IgAScience immunology · 2024Article
- High Serum miR-361-3p Predicts Early Postdischarge Infections after Autologous Stem Cell Transplantation.Infection & chemotherapy · 2024Article
- From Gene to Protein-How Bacterial Virulence Factors Manipulate Host Gene Expression During Infection.International journal of molecular sciences · 2020Review
- Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.PLoS pathogens · 2020Article
- Bacteria That Cause Enteric Diseases Stimulate Distinct Humoral Immune Responses.Frontiers in immunology · 2020Review
- Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction.Microbiology spectrum · 2019Review
- Citrobacter rodentium alters the mouse colonic miRNome.Genes and immunity · 2019Article
- Role of miR-155 in immune regulation and its relevance in oral lichen planus.Experimental and therapeutic medicine · 2019Review
- Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk.Seminars in cell & developmental biology · 2017Review
- A non-endoscopic device to sample the oesophageal microbiota: a case-control study.The lancet. Gastroenterology & hepatology · 2017Article
- Circulating microRNAs as Potential Biomarkers of Infectious Disease.Frontiers in immunology · 2017Review
- Role of MicroRNAs in NAFLD/NASH.Digestive diseases and sciences · 2016Review
- Noncoding RNAs and chronic inflammation: Micro-managing the fire within.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Citrobacter rodentium: infection, inflammation and the microbiota.Nature reviews. Microbiology · 2014Review
- Complete Genome Sequences of Two Citrobacter rodentium Bacteriophages, CR8 and CR44b.Genome announcements · 2014Article
- MicroRNAs and the regulation of intestinal homeostasis.Frontiers in genetics · 2014Review
- Small RNA-mediated regulation of host-pathogen interactions.Virulence · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
MicroRNAs (miRNAs) are small noncoding molecules that control gene expression posttranscriptionally, with microRNA-155 (miR-155) one of the first to be implicated in immune regulation. Here, we show that miR-155-deficient mice are less able to eradicate a mucosal Citrobacter rodentium infection than wild-type C57BL/6 mice. miR-155-deficient mice exhibited prolonged colonization associated with a higher C. rodentium burden in gastrointestinal tissue and spread into systemic tissues. Germinal center formation and humoral immune responses against C. rodentium were severely impaired in infected miR-155-deficient mice. A similarly susceptible phenotype was observed in μMT mice reconstituted with miR-155-deficient B cells, indicating that miR-155 is required intrinsically for mediating protection against this predominantly luminal bacterial pathogen.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.