Evidence map›Paper›PMID 23263797›Full record

ArticleInternational journal of clinical pharmacy2013

Pediatric drug-related problems: a multicenter study in four French-speaking countries.

Sonia Prot-Labarthe, Ermindo R Di Paolo, Annie Lavoie, Stefanie Quennery, Jean-François Bussières, Françoise Brion, Olivier Bourdon

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of clinical pharmacy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  19. Relation between safe use of medicines and Clinical Pharmacy Services at Pediatric Intensive Care Units.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Sonia Prot-LabarthePharmacy Department, APHP, Hôpital Robert Debré, 48, boulevard Sérurier, 75019, Paris, France.
Ermindo R Di Paolo
Annie Lavoie
Stefanie Quennery
Jean-François Bussières
Françoise Brion
Olivier Bourdon
Assistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Universitaire Sainte-Justine · CACliniques Universitaires Saint-Luc · BEDélégation Paris 5 · FRUniversité de Montréal · CAUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric intensive care patients represent a population at high risk for drug-related problems. There are few studies that compare the activity of clinical pharmacists between countries.

objectiveTo describe the drug-related problems identified and interventions by four pharmacists in a pediatric cardiac and intensive care unit.

settingFour pediatric centers in France, Quebec, Switzerland and Belgium.

methodThis was a six-month multicenter, descriptive and prospective study conducted from August 1, 2009 to January 31, 2010. Drug-related problems and clinical interventions were compiled from four pediatric centers in France, Quebec, Switzerland and Belgium. Data on patients, drugs, intervention, documentation, approval and estimated impact were compiled.

main outcome measureNumber and type of drug-related problems encountered in a large pediatric inpatient population.

resultsA total of 996 interventions were recorded: 238 (24 %) in France, 278 (28 %) in Quebec, 351 (35 %) in Switzerland and 129 (13 %) in Belgium. These interventions targeted 270 patients (median 21 months old, 53 % male): 88 (33 %) in France, 56 (21 %) in Quebec, 57 (21 %) in Switzerland and 69 (26 %) in Belgium. The main drug-related problems were inappropriate administration technique (29 %), untreated indication (25 %) and supra-therapeutic dose (11 %). The pharmacists' interventions were mostly optimizing the mode of administration (22 %), dose adjustment (20 %) and therapeutic monitoring (16 %). The two major drug classes that led to interventions were anti-infectives for systemic use (23 %) and digestive system and metabolism drugs (22 %). Interventions mainly involved residents and all clinical staff (21 %). Among the 878 (88 %) proposed interventions requiring physician approval, 860 (98 %) were accepted.

conclusionThis descriptive study illustrates drug-related problems and the ability of clinical pharmacists to identify and resolve them in pediatric intensive care units in four French-speaking countries.

Indexed as

Drug-Related Side Effects and Adverse ReactionsAdolescentBelgiumChildChild, PreschoolDose-Response Relationship, DrugFemaleFranceHumansInfantInfant, NewbornIntensive Care UnitsMaleMedication ErrorsPharmaceutical PreparationsPharmacistsPharmaceutical Preparations

Identifiers

PMID23263797
OpenAlexW1983067040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.