ArticlePediatric nephrology (Berlin, Germany)2013
Close association between proteinuria and regulatory T cells in patients with idiopathic nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- New Insights into the Treatment of Glomerular Diseases: When Mechanisms Become Vivid.International journal of molecular sciences · 2022Review
- Trends in pediatric nephrotic syndrome.World journal of nephrology · 2021Review
- Long-term Successful Treatment of Rituximab for Steroid-resistant Minimal Change Nephrotic Syndrome and Idiopathic Thrombocytopenic Purpura.Internal medicine (Tokyo, Japan) · 2020Article
- Pediatric Patients With Steroid-Sensitive Nephrotic Syndrome Have Higher Expression of T Regulatory Lymphocytes in Comparison to Steroid-Resistant Disease.Frontiers in pediatrics · 2019Article
- Rituximab in Minimal Change Disease: Mechanisms of Action and Hypotheses for Future Studies.Canadian journal of kidney health and disease · 2017Review
- Benign acute childhood myositis complicating influenza B infection in a boy with idiopathic nephrotic syndrome.Central-European journal of immunology · 2016Article
- Viral-associated glomerulopathies in children.Pediatric nephrology (Berlin, Germany) · 2015Review
- Regulatory and effector T cells changes in remission and resistant state of childhood nephrotic syndrome.Indian journal of nephrology · 2014Article
- A Case of Nephrotic Syndrome that Resolved with Influenza B Infection.Case reports in nephrology and dialysisArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic nephrotic syndrome (INS) has been considered to be a T cell disorder. Supporting this hypothesis is the reported occurrence of remission following measles infection, which suppresses T cell function. In contrast, there has been no case report suggesting an association between influenza B virus infection and the remission of INS. CASE-DIAGNOSIS/TREATMENT: We report the case of a 5-year-old boy with INS who achieved remission without steroid treatment in response to influenza B virus infection. Although he relapsed soon after remission, he was successfully treated with prednisolone. Both the induction of remission and the response to prednisolone were associated with an increase in the number of circulating regulatory T cells (Tregs), assessed as CD4(+)CD25(+)Foxp3(+) cells. These results suggest that both influenza B virus infection and steroid administration increased the number of circulating Tregs, thus leading to the remission of INS.
conclusionsIn summary, our case indicates an important role for Tregs in the development of the proteinuria associated with INS and sheds light on its pathogenesis. Further studies are warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.